Mucoepidermoid carcinoma classification: Difference between revisions
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** The Brandwein<ref name="pmid12484654">{{cite journal |vauthors=Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A |title=Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes |journal=Acta Otolaryngol. |volume=122 |issue=7 |pages=758–64 |date=October 2002 |pmid=12484654 |doi= |url=}}</ref> | ** The Brandwein<ref name="pmid12484654">{{cite journal |vauthors=Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A |title=Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes |journal=Acta Otolaryngol. |volume=122 |issue=7 |pages=758–64 |date=October 2002 |pmid=12484654 |doi= |url=}}</ref> | ||
* All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion. | * All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion. | ||
* | |||
{| class="wikitable sortable" | |||
|+ | |||
!Category | |||
!Histopathologic findings | |||
|- | |||
|Low grade | |||
| | |||
* Macrocysts, microcysts, | |||
* Transition with excretory ducts, | |||
* Differentiated Mucin producing Epidermoid Cells, often in a 1:1 ratio, minimal to moderate intermediate cell population | |||
* Daughter cyst proliferation from large cysts | |||
* Minimal to absent pleomorphism, rare mitoses | |||
* Broad-front, often circumscribed invasion | |||
* Pools of extravasated mucin with stromal reaction | |||
|- | |||
|Intermediated grade | |||
| | |||
* No macrocysts, few microcysts, | |||
* Solid nests of cells, | |||
* Large duct not conspicuous, | |||
* Slight to moderate pleomorphism, few mitoses, prominent nuclei and nucleoli | |||
* Invasive quality, usually well defined and uncircumscribed | |||
* Chronic inflammation at periphery | |||
* Fibrosis separates nests of cells and groups of nests | |||
|- | |||
|High grade | |||
| | |||
* No macrocysts, | |||
* Predominantly solid but may be nearly all glandular | |||
* Cell constituents range from poorly differentiated to recognizable epidermoid and intermediate to ductal type adenocarcinoma | |||
* Considerable pleomorphism, mitoses | |||
* Unquestionable soft tissue, perineural and intravascular invasion | |||
* Chronic inflammation less prominent, desmoplasia of stroma may outline invasive clusters | |||
|} | |||
==References== | ==References== | ||
Revision as of 08:24, 8 January 2019
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Mucoepidermoid carcinoma Microchapters |
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Differentiating Mucoepidermoid Carcinoma from other Diseases |
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Diagnosis |
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Mucoepidermoid carcinoma classification On the Web |
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American Roentgen Ray Society Images of Mucoepidermoid carcinoma classification |
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Risk calculators and risk factors for Mucoepidermoid carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] Maria Fernanda Villarreal, M.D. [3]
Overview
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas.
Classification
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:[1]
| Classification: Mucoepidermoid Carcinomas Adapted from Radiopedia [1] |
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|---|---|---|
| Salivary gland-confined carcinomas |
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| Other organ mucoepidermoid carcinomas |
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Grading based on Histopathology:
- Mucoepidermoid carcinoma are graded into three subtypes based on histpathological features:
- Low
- Intermediate
- High grade
- The three most popular grading systems are:
- All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.
| Category | Histopathologic findings |
|---|---|
| Low grade |
|
| Intermediated grade |
|
| High grade |
|
References
- ↑ 1.0 1.1 Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016
- ↑ Goode RK, Auclair PL, Ellis GL (April 1998). "Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria". Cancer. 82 (7): 1217–24. PMID 9529011.
- ↑ Batsakis JG, Luna MA (October 1990). "Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas". Ann. Otol. Rhinol. Laryngol. 99 (10 Pt 1): 835–8. doi:10.1177/000348949009901015. PMID 2221741.
- ↑ Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A (October 2002). "Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes". Acta Otolaryngol. 122 (7): 758–64. PMID 12484654.