Burkitt's lymphoma medical therapy: Difference between revisions
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The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref Name= Cancer.ca>Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref Name= Cancer.ca>Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
* Chemotherapeutic regimens for Burkitt's lymphoma include: | * Chemotherapeutic regimens for Burkitt's lymphoma include:<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | ||
* [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Methotrexate]] (CODOX-M)<ref name="pmid29741758">{{cite journal| author=Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K et al.| title=Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab. | journal=Br J Haematol | year= 2018 | volume= 181 | issue= 6 | pages= 782-790 | pmid=29741758 | doi=10.1111/bjh.15262 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29741758 }} </ref> | * [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Methotrexate]] (CODOX-M)<ref name="pmid29741758">{{cite journal| author=Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K et al.| title=Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab. | journal=Br J Haematol | year= 2018 | volume= 181 | issue= 6 | pages= 782-790 | pmid=29741758 | doi=10.1111/bjh.15262 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29741758 }} </ref> | ||
* [[Ifosfamide]] {{and}} [[Mesna]] {{and}} [[Etoposide]] {{and}} [[Cytarabine]] (IVAC) | * [[Ifosfamide]] {{and}} [[Mesna]] {{and}} [[Etoposide]] {{and}} [[Cytarabine]] (IVAC) | ||
* [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Dexamethasone]] {{and}} [[Methotrexate]] {{and}} [[Cytarabine]] (Hyper-CVAD) | * [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Dexamethasone]] {{and}} [[Methotrexate]] {{and}} [[Cytarabine]] (Hyper-CVAD) | ||
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* CNS prophylaxis may involve giving [[intrathecal]] chemotherapy, high doses of systemic therapy, or both methods may be used | * CNS prophylaxis may involve giving [[intrathecal]] chemotherapy, high doses of systemic therapy, or both methods may be used | ||
* [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | * [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | ||
===Biological therapy=== | ===Biological therapy=== | ||
* [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | * [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | ||
* [[Rituximab]] may be added to each of the above chemotherapy regimens | * [[Rituximab]] may be added to each of the above chemotherapy regimens<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | ||
===Stem cell transplant=== | ===Stem cell transplant=== | ||
* A [[stem cell transplant]] may be offered to patients with recurrent Burkitt's lymphoma or to patients who relapse after the treatment. | * A [[stem cell transplant]] may be offered to patients with recurrent Burkitt's lymphoma or to patients who relapse after the treatment.<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | ||
==References== | ==References== | ||
Revision as of 21:31, 8 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.
Medical Therapy
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.[1]
Chemotherapy
- Chemotherapeutic regimens for Burkitt's lymphoma include:[2]
* Cyclophosphamide AND Vincristine AND Doxorubicin AND Methotrexate (CODOX-M)[3]
- Ifosfamide AND Mesna AND Etoposide AND Cytarabine (IVAC)
- Cyclophosphamide AND Vincristine AND Doxorubicin AND Dexamethasone AND Methotrexate AND Cytarabine (Hyper-CVAD)
CNS prophylaxis
- There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
- CNS prophylaxis may involve giving intrathecal chemotherapy, high doses of systemic therapy, or both methods may be used
- Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis
Biological therapy
- Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma
- Rituximab may be added to each of the above chemotherapy regimens[2]
Stem cell transplant
- A stem cell transplant may be offered to patients with recurrent Burkitt's lymphoma or to patients who relapse after the treatment.[2]
References
- ↑ Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015
- ↑ 2.0 2.1 2.2 Jacobson, C.; LaCasce, A. (2014). "How I treat Burkitt lymphoma in adults". Blood. 124 (19): 2913–2920. doi:10.1182/blood-2014-06-538504. ISSN 0006-4971.
- ↑ Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K; et al. (2018). "Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab". Br J Haematol. 181 (6): 782–790. doi:10.1111/bjh.15262. PMID 29741758.