SOX17

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

SRY-box 17 is a protein that in humans is encoded by the SOX17 gene.

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

Further reading

• Zhang W, Glöckner SC, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB (2008). "Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer". Cancer Res. 68 (8): 2764–72. doi:10.1158/0008-5472.CAN-07-6349. PMC 2823123. PMID 18413743.
• Patterson ES, Addis RC, Shamblott MJ, Gearhart JD (2008). "SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation". Physiol. Genomics. 34 (3): 277–84. doi:10.1152/physiolgenomics.90236.2008. PMID 18523156.
• Ferrell RE, Kimak MA, Lawrence EC, Finegold DN (2008). "Candidate gene analysis in primary lymphedema". Lymphat Res Biol. 6 (2): 69–76. doi:10.1089/lrb.2007.1022. PMID 18564921.
• Séguin CA, Draper JS, Nagy A, Rossant J (2008). "Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells". Cell Stem Cell. 3 (2): 182–95. doi:10.1016/j.stem.2008.06.018. PMID 18682240.
• Semb H (2008). "Expandable endodermal progenitors: new tools to explore endoderm and its derivatives". Cell Stem Cell. 3 (4): 355–6. doi:10.1016/j.stem.2008.09.010. PMID 18940723.
• Fu DY, Wang ZM, Li-Chen, Wang BL, Shen ZZ, Huang W, Shao ZM (2010). "Sox17, the canonical Wnt antagonist, is epigenetically inactivated by promoter methylation in human breast cancer". Breast Cancer Res. Treat. 119 (3): 601–12. doi:10.1007/s10549-009-0339-8. PMID 19301122.
• Nonaka D (2009). "Differential expression of SOX2 and SOX17 in testicular germ cell tumors". Am. J. Clin. Pathol. 131 (5): 731–6. doi:10.1309/AJCP7MNCNBCRN8NO. PMID 19369635.
• Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Kotani H, Taketo MM, Oshima M (2009). "Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis". Gastroenterology. 137 (4): 1346–57. doi:10.1053/j.gastro.2009.06.041. PMID 19549530.
• Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M (2009). "Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate". J. Cell Biol. 186 (5): 665–73. doi:10.1083/jcb.200901040. PMC 2742180. PMID 19736317.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.