CASPR: Difference between revisions

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{{Underlinked|date=May 2014}}
{{Underlinked|date=May 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''CASPR''' also known as '''Contactin associated protein 1''', '''Paranodin''' and '''CASPR1''' is a [[protein]] that in humans is encoded by the CNTNAP1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Contactin associated protein 1 | url = https://www.ncbi.nlm.nih.gov/gene/8506 }}</ref>
'''CASPR''' also known as '''Contactin associated protein 1''', '''Paranodin''' and '''CASPR1''' is a [[protein]] that in humans is encoded by the CNTNAP1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Contactin associated protein 1 | url = https://www.ncbi.nlm.nih.gov/gene/8506 }}</ref>
CASPR is a part of the [[neurexin]] family of proteins, hence its another name "'''Neurexin IV'''".<ref>{{Cite web|url=https://omim.org/entry/602346|title=OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1|website=omim.org|language=en-us|access-date=2017-04-27}}</ref> CASPR is a membrane protein found in the neuronal membrane in the [[paranodal]] section of the axon in [[myelinated]] neurons, between the [[Nodes of Ranvier]] containing Na+ channels, and juxtaparanode, which contains K+ channels.<ref name="ref1">{{cite journal|url=http://www.jneurosci.org/content/20/22/8354|title=Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during Myelination|first1=Jose C.|last1=Rios|first2=Carmen V.|last2=Melendez-Vasquez|first3=Steven|last3=Einheber|first4=Marc|last4=Lustig|first5=Martin|last5=Grumet|first6=John|last6=Hemperly|first7=Elior|last7=Peles|first8=James L.|last8=Salzer|date=15 November 2000|publisher=|journal=J. Neurosci.|volume=20|issue=22|pages=8354–8364|via=www.jneurosci.org|pmid=11069942}}</ref> During myelination, caspr associates with contactin in a ''cis'' complex,<ref name="ref1"/> though its precise role in myelination is not yet understood.
CASPR is a part of the [[neurexin]] family of proteins, hence its another name "'''Neurexin IV'''".<ref>{{Cite web|url=https://omim.org/entry/602346|title=OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1|website=omim.org|language=en-us|access-date=2017-04-27}}</ref> CASPR is a membrane protein found in the neuronal membrane in the [[paranodal]] section of the axon in [[myelinated]] neurons, between the [[Nodes of Ranvier]] containing Na+ channels, and juxtaparanode, which contains K+ channels.<ref name="ref1">{{cite journal|url=http://www.jneurosci.org/content/20/22/8354|title=Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during Myelination|first1=Jose C.|last1=Rios|first2=Carmen V.|last2=Melendez-Vasquez|first3=Steven|last3=Einheber|first4=Marc|last4=Lustig|first5=Martin|last5=Grumet|first6=John|last6=Hemperly|first7=Elior|last7=Peles|first8=James L.|last8=Salzer|date=15 November 2000|publisher=|journal=J. Neurosci.|volume=20|issue=22|pages=8354–8364|via=www.jneurosci.org|pmid=11069942}}</ref> During myelination, caspr associates with contactin in a ''cis'' complex,<ref name="ref1"/> though its precise role in myelination is not yet understood.
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== References ==
== References ==
 
{{Reflist}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CNTNAP1}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S | title = Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration | journal = Journal of Proteome Research | volume = 11 | issue = 4 | pages = 2533–43 | date = April 2012 | pmid = 22360420 | doi = 10.1021/pr2012279 }}
* {{cite journal | vauthors = Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S | title = Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration | journal = Journal of Proteome Research | volume = 11 | issue = 4 | pages = 2533–43 | date = April 2012 | pmid = 22360420 | doi = 10.1021/pr2012279 }}
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* {{cite journal | vauthors = Charles P, Tait S, Faivre-Sarrailh C, Barbin G, Gunn-Moore F, Denisenko-Nehrbass N, Guennoc AM, Girault JA, Brophy PJ, Lubetzki C | title = Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction | journal = Current Biology | volume = 12 | issue = 3 | pages = 217–20 | date = February 2002 | pmid = 11839274 | doi = 10.1016/S0960-9822(01)00680-7 }}
* {{cite journal | vauthors = Charles P, Tait S, Faivre-Sarrailh C, Barbin G, Gunn-Moore F, Denisenko-Nehrbass N, Guennoc AM, Girault JA, Brophy PJ, Lubetzki C | title = Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction | journal = Current Biology | volume = 12 | issue = 3 | pages = 217–20 | date = February 2002 | pmid = 11839274 | doi = 10.1016/S0960-9822(01)00680-7 }}
* {{cite journal | vauthors = Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC | title = Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization | journal = The EMBO Journal | volume = 22 | issue = 21 | pages = 5666–78 | date = November 2003 | pmid = 14592966 | pmc = 275427 | doi = 10.1093/emboj/cdg570 }}
* {{cite journal | vauthors = Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC | title = Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization | journal = The EMBO Journal | volume = 22 | issue = 21 | pages = 5666–78 | date = November 2003 | pmid = 14592966 | pmc = 275427 | doi = 10.1093/emboj/cdg570 }}
{{refend}}


{{refend}}
==External links==
* {{UCSC gene info|CNTNAP1}}


{{NLM content}}
{{NLM content}}

Latest revision as of 09:07, 4 January 2019

Not to be confused with CRISPR.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene.[1] CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV".[2] CASPR is a membrane protein found in the neuronal membrane in the paranodal section of the axon in myelinated neurons, between the Nodes of Ranvier containing Na+ channels, and juxtaparanode, which contains K+ channels.[3] During myelination, caspr associates with contactin in a cis complex,[3] though its precise role in myelination is not yet understood.

Function

The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009].

Mutations in CNTNAP1 cause arthrogryposis multiplex congenita .[4]

References

  1. ↑ "Entrez Gene: Contactin associated protein 1".
  2. ↑ "OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1". omim.org. Retrieved 2017-04-27.
  3. ↑ 3.0 3.1 Rios, Jose C.; Melendez-Vasquez, Carmen V.; Einheber, Steven; Lustig, Marc; Grumet, Martin; Hemperly, John; Peles, Elior; Salzer, James L. (15 November 2000). "Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during Myelination". J. Neurosci. 20 (22): 8354–8364. PMID 11069942 – via www.jneurosci.org.
  4. ↑ Laquérriere A, Maluenda J, Camus A, Fontenas L, Dieterich K, Nolent F, et al. (May 2014). "Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects". Human Molecular Genetics. 23 (9): 2279–89. doi:10.1093/hmg/ddt618. PMID 24319099.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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