Stomach cancer causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
== Stomach cancer causes == | == Stomach cancer causes == | ||
Causes of [[stomach cancer]] depend upon the type of [[cancer]]:<ref name="pmid27722154">{{cite journal |vauthors=Cheng XJ, Lin JC, Tu SP |title=Etiology and Prevention of Gastric Cancer |journal=Gastrointest Tumors |volume=3 |issue=1 |pages=25–36 |date=September 2016 |pmid=27722154 |pmc=5040890 |doi=10.1159/000443995 |url=}}</ref> | Causes of [[stomach cancer]] depend upon the type of [[cancer]]:<ref name="pmid27722154">{{cite journal |vauthors=Cheng XJ, Lin JC, Tu SP |title=Etiology and Prevention of Gastric Cancer |journal=Gastrointest Tumors |volume=3 |issue=1 |pages=25–36 |date=September 2016 |pmid=27722154 |pmc=5040890 |doi=10.1159/000443995 |url=}}</ref><ref name="pmid23639637">{{cite journal |vauthors=Correa P |title=Gastric cancer: overview |journal=Gastroenterol. Clin. North Am. |volume=42 |issue=2 |pages=211–7 |date=June 2013 |pmid=23639637 |pmc=3995345 |doi=10.1016/j.gtc.2013.01.002 |url=}}</ref><ref name="pmid15367571">{{cite journal |vauthors=Corley DA, Kubo A |title=Influence of site classification on cancer incidence rates: an analysis of gastric cardia carcinomas |journal=J. Natl. Cancer Inst. |volume=96 |issue=18 |pages=1383–7 |date=September 2004 |pmid=15367571 |doi=10.1093/jnci/djh265 |url=}}</ref> | ||
==== Adenocarcinoma ==== | ==== Adenocarcinoma ==== | ||
* [[Adenocarcinomas]] are caused by [[genetic]] modulations due to [[chronic inflammation]] mainly by [[H. pylori]] [[bacteria]]. | * [[Adenocarcinomas]] are caused by [[genetic]] modulations due to [[chronic inflammation]] mainly by [[H. pylori]] [[bacteria]].<ref name="pmid15367571">{{cite journal |vauthors=Corley DA, Kubo A |title=Influence of site classification on cancer incidence rates: an analysis of gastric cardia carcinomas |journal=J. Natl. Cancer Inst. |volume=96 |issue=18 |pages=1383–7 |date=September 2004 |pmid=15367571 |doi=10.1093/jnci/djh265 |url=}}</ref> | ||
* ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and [[intestinal]] [[metaplasia]]. | * ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and [[intestinal]] [[metaplasia]]. | ||
* [[Hepatocyte growth factor]] [[Receptor (biochemistry)|receptor]] c''-met'' [[oncogene]] is found in intestinal-type [[Gastric cancer|gastric cancers]]. | * [[Hepatocyte growth factor]] [[Receptor (biochemistry)|receptor]] c''-met'' [[oncogene]] is found in intestinal-type [[Gastric cancer|gastric cancers]]. | ||
Revision as of 15:35, 15 January 2019
|
Stomach cancer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Stomach cancer causes On the Web |
|
American Roentgen Ray Society Images of Stomach cancer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Causes of stomach cancer depend on the type of cancer. Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori infection. Diffuse gastric carcinomas do not have a precancerous lesion. Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.
Stomach cancer causes
Causes of stomach cancer depend upon the type of cancer:[1][2][3]
Adenocarcinoma
- Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria.[3]
- K-ras mutations oncogenes are found in invasive cancers and intestinal metaplasia.
- Hepatocyte growth factor receptor c-met oncogene is found in intestinal-type gastric cancers.
- Almost 50% of gastric cancers have alterations in genes TP53, TP73, APC, TFF, DCC, LOH, and FHIT.
- Inactivation of p53 in gastric epithelial cells reduce their ability to undergo apoptosis.
Diffuse gastric carcinoma
- Diffuse gastric carcinomas do not have a precancerous lesion.
- Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.
- Prostate stem cell antigen gene is also involved in regulating gastric epithelial cell proliferation. Its cytoplasmic tail interacts with catenins making the adhesion.
References
- ↑ Cheng XJ, Lin JC, Tu SP (September 2016). "Etiology and Prevention of Gastric Cancer". Gastrointest Tumors. 3 (1): 25–36. doi:10.1159/000443995. PMC 5040890. PMID 27722154.
- ↑ Correa P (June 2013). "Gastric cancer: overview". Gastroenterol. Clin. North Am. 42 (2): 211–7. doi:10.1016/j.gtc.2013.01.002. PMC 3995345. PMID 23639637.
- ↑ 3.0 3.1 Corley DA, Kubo A (September 2004). "Influence of site classification on cancer incidence rates: an analysis of gastric cardia carcinomas". J. Natl. Cancer Inst. 96 (18): 1383–7. doi:10.1093/jnci/djh265. PMID 15367571.