Merkel cell cancer risk factors: Difference between revisions
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* Common risk factors in the development of [[merkel cell cancer]] may be occupational, environmental, genetic, and viral. | * Common risk factors in the development of [[merkel cell cancer]] may be occupational, environmental, genetic, and viral. | ||
* Common risk factors for the development of [[merkel cell cancer]] include:<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref> | * Common risk factors for the development of [[merkel cell cancer]] include:<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref><ref name="pmid300858322">{{cite journal |vauthors=Schmerling RA, Casas JG, Cinat G, Ospina FEG, Kassuga LEBP, Tlahuel JLM, Mazzuoccolo LD |title=Burden of Disease, Early Diagnosis, and Treatment of Merkel Cell Carcinoma in Latin America |journal=J Glob Oncol |volume= |issue=4 |pages=1–11 |date=July 2018 |pmid=30085832 |pmc=6223512 |doi=10.1200/JGO.18.00041 |url=}}</ref> | ||
** [[Mutations]] in the [[DNA]] due to polyomaviruses | ** [[Mutations]] in the [[DNA]] due to polyomaviruses | ||
** Chronic exposure to [[sunlight]] | ** Chronic exposure to [[sunlight]] | ||
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=== Less Common Risk Factors === | === Less Common Risk Factors === | ||
* Less common risk factors in the development of [[merkel cell cancer]] include:<ref name="pmid29102486">{{cite journal |vauthors=Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P |title=Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics |journal=J. Am. Acad. Dermatol. |volume=78 |issue=3 |pages=457–463.e2 |date=March 2018 |pmid=29102486 |doi=10.1016/j.jaad.2017.10.028 |url=}}</ref><ref name="pmid19638070">{{cite journal |vauthors=Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE |title=Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study |journal=J. Cutan. Pathol. |volume=37 |issue=1 |pages=20–7 |date=January 2010 |pmid=19638070 |doi=10.1111/j.1600-0560.2009.01370.x |url=}}</ref> | * Less common risk factors in the development of [[merkel cell cancer]] include:<ref name="pmid29102486">{{cite journal |vauthors=Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P |title=Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics |journal=J. Am. Acad. Dermatol. |volume=78 |issue=3 |pages=457–463.e2 |date=March 2018 |pmid=29102486 |doi=10.1016/j.jaad.2017.10.028 |url=}}</ref><ref name="pmid19638070">{{cite journal |vauthors=Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE |title=Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study |journal=J. Cutan. Pathol. |volume=37 |issue=1 |pages=20–7 |date=January 2010 |pmid=19638070 |doi=10.1111/j.1600-0560.2009.01370.x |url=}}</ref><ref name="pmid30085832">{{cite journal |vauthors=Schmerling RA, Casas JG, Cinat G, Ospina FEG, Kassuga LEBP, Tlahuel JLM, Mazzuoccolo LD |title=Burden of Disease, Early Diagnosis, and Treatment of Merkel Cell Carcinoma in Latin America |journal=J Glob Oncol |volume= |issue=4 |pages=1–11 |date=July 2018 |pmid=30085832 |pmc=6223512 |doi=10.1200/JGO.18.00041 |url=}}</ref> | ||
** Old [[age]] > 70 years | ** Old [[age]] > 70 years | ||
** Male gender | ** Male gender |
Revision as of 15:59, 15 January 2019
Merkel cell cancer Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Risk factors for the development of merkel cell cancer include old age, male gender, caucasian race, chronic exposure to sunlight, immunodeficiency, and personal history of cancer.
Risk Factors
Common Risk Factors
- Common risk factors in the development of merkel cell cancer may be occupational, environmental, genetic, and viral.
- Common risk factors for the development of merkel cell cancer include:[1][2]
- Mutations in the DNA due to polyomaviruses
- Chronic exposure to sunlight
- Immunodeficiency or administration of immunosuppressive pharmacologic agents
Less Common Risk Factors
- Less common risk factors in the development of merkel cell cancer include:[3][4][5]
References
- ↑ Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.
- ↑ Schmerling RA, Casas JG, Cinat G, Ospina F, Kassuga L, Tlahuel J, Mazzuoccolo LD (July 2018). "Burden of Disease, Early Diagnosis, and Treatment of Merkel Cell Carcinoma in Latin America". J Glob Oncol (4): 1–11. doi:10.1200/JGO.18.00041. PMC 6223512. PMID 30085832. Vancouver style error: initials (help)
- ↑ Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P (March 2018). "Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics". J. Am. Acad. Dermatol. 78 (3): 457–463.e2. doi:10.1016/j.jaad.2017.10.028. PMID 29102486.
- ↑ Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE (January 2010). "Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study". J. Cutan. Pathol. 37 (1): 20–7. doi:10.1111/j.1600-0560.2009.01370.x. PMID 19638070.
- ↑ Schmerling RA, Casas JG, Cinat G, Ospina F, Kassuga L, Tlahuel J, Mazzuoccolo LD (July 2018). "Burden of Disease, Early Diagnosis, and Treatment of Merkel Cell Carcinoma in Latin America". J Glob Oncol (4): 1–11. doi:10.1200/JGO.18.00041. PMC 6223512. PMID 30085832. Vancouver style error: initials (help)