Merkel cell cancer natural history: Difference between revisions
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===Prognosis=== | ===Prognosis=== | ||
*Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis. If diagnosed early, | *Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis. | ||
*If diagnosed early, merkel cell cancer has a good prognosis with a 5-year survival rate of approximately 90%. | |||
*The prognosis depend on the following:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq</ref> | *The prognosis depend on the following:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq</ref> | ||
**Stage at diagnosis (1st most potent prognostic factor) | |||
**Lymph Node involvement (2nd most important prognostic factor) | |||
**Merkel cell polyomavirus (MCPyV) viral load also play an significant role in prognosis of merkel cell cancer | |||
**Cancer location | |||
**Cancer depth | |||
**Primary vs recurrent | |||
*'''Lymphovascular invasion''' in merkel cell cancer patients associated with poor prognosis | |||
*'''Intratumoral lymphocyte infiltration''' in merkel cell cancer patients associated with good prognosis due to presence of CD8+ lymphocyte infiltration | |||
*'''p63 expression''' | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 13:55, 16 January 2019
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Merkel cell cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Merkel cell cancer natural history On the Web |
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American Roentgen Ray Society Images of Merkel cell cancer natural history |
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Risk calculators and risk factors for Merkel cell cancer natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Merkel cell cancer is an aggressive skin tumor that grows rapidly. It usually metastasizes first to regional lymph nodes and then to other distant organs. and spreads to other parts of the body, especially the liver, lungs, brain and bones. Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis. If diagnosed early, Merkel cell cancer has a good prognosis with a 5-year survival rate of approximately 90%.
Natural History, Complications, and Prognosis
Natural History
- Merkel cell cancer is an aggressive skin tumor that grows rapidly.
- It usually metastasizes first to regional lymph nodes and then to other distant organs. and spreads to other parts of the body, especially the liver, lungs, brain and bones.
Complications
Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- [Complication 3]
Prognosis
- Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis.
- If diagnosed early, merkel cell cancer has a good prognosis with a 5-year survival rate of approximately 90%.
- The prognosis depend on the following:[1]
- Stage at diagnosis (1st most potent prognostic factor)
- Lymph Node involvement (2nd most important prognostic factor)
- Merkel cell polyomavirus (MCPyV) viral load also play an significant role in prognosis of merkel cell cancer
- Cancer location
- Cancer depth
- Primary vs recurrent
- Lymphovascular invasion in merkel cell cancer patients associated with poor prognosis
- Intratumoral lymphocyte infiltration in merkel cell cancer patients associated with good prognosis due to presence of CD8+ lymphocyte infiltration
- p63 expression
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq