Sandbox:Hannan1

Neuroendocrine tumor		Clinical manifestations		Dianosis						Other features
		Symptoms	Signs	Blood	Gross	Histology	Immunohistochemistry	Imaging	Gold standard
Medullary thyroid carcinoma		Dysphagia Hoarseness Respiratory difficulty Flushing Diarrhea Weight loss Cushing syndrome	Palpable neck mass Signs of Cushing syndrome	↑ Calcitonin ↑ Serum calcium ↑ or - Cortisol ↑ CEA level	White or gray in color Firm to palpation	Nests of uniform cells Deposition of stromal amyloid Granular chromatin C-cell hyperplasia	Calcitonin Chromogranin A Carcinoembryonic antigen (CEA)	Solid thyroid nodule (US) CT scan/MRI/PET scan for metastatis
Pheochromocytoma
Merkel cell carcinoma
Parathyroid adenoma
Paraganglioma
Pituitary gland tumors
Neuroendocrine tumors of the ovaries or testicles
Thymic neuroendocrine cancer
Lung neuroendocrine tumors	Typical carcinoid tumours
	Atypical carcinoid tumours
	Large cell lung neuroendocrine carcinomas
	Small cell lung neuroendocrine carcinomas
Pancreatic neuroendocrine tumours	Gastrinoma
	Insulinoma
	Glucagonoma
	Somatostatinoma
	VIPoma
	ACTHoma
Gastric neuroendocrine tumors	Type I GNET
	Type II GNET
	Type III GNET
	Type IV GNET
Duodenal neuroendocrine tumors	Gastrinomas
	Somatostatinomas
	Gangliocytic paraganglionomas
	Nonfunctioning NET
	neuroendocrine carcinomas
Jejuno-Ileal neuroendocrine tumors
Appendix neuroendocrine tumors
Colon neuroendocrine tumors
Rectum neuroendocrine tumors