Chronic neutrophilic leukemia diagnostic study of choice: Difference between revisions
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! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |World Health Organization (WHO) Criteria for CNL | ! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |[[World Health Organization]] (WHO) [[Criteria]] for CNL [[diagnosis]] | ||
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! style="background: #DCDCDC; text-align: center;" |1. Peripheral blood White blood cells(WBC) ≥25 × 109/L: | ! style="background: #DCDCDC; text-align: center;" |1. [[Peripheral blood]] [[White blood cells]][[(WBC)]] ≥25 × 109/L: | ||
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* Segmented neutrophils plus band forms ≥80% of WBC | * Segmented neutrophils plus band forms ≥80% of WBC | ||
Revision as of 20:52, 22 January 2019
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Chronic neutrophilic leukemia Microchapters |
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Differentiating Chronic neutrophilic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Chronic neutrophilic leukemia diagnostic study of choice On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
World health organization (WHO) introduces criteria for the diagnosis of chronic neutrophilic leukemia (CNL) that are based on the laboratory finding of peripheral blood cells, bone marrow, cytogenic mutation, and differential diagnosis.
Diagnostic Study of Choice
Study of choice
The diagnosis of CNL is based on the WHO criteria, which include:[1]
| World Health Organization (WHO) Criteria for CNL diagnosis | |
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| 1. Peripheral blood White blood cells(WBC) ≥25 × 109/L: |
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| 2. Hypercellular bone marrow: |
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| 3. Not meeting WHO criteria for: |
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| 4.No rearrangement of: |
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| 5.Presence of CSF3RT618I or other activating CSF3R mutation or
In the absence of a CSFR3R mutation, persistent neutrophilia (at least 3 months), splenomegaly, and no identifiable cause of reactive neutrophilia including the absence of a plasma cell neoplasm or, if present, demonstration of clonality of myeloid cells by cytogenetic or molecular studies. | |
References
- ↑ Arber, D. A.; Orazi, A.; Hasserjian, R.; Thiele, J.; Borowitz, M. J.; Le Beau, M. M.; Bloomfield, C. D.; Cazzola, M.; Vardiman, J. W. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–2405. doi:10.1182/blood-2016-03-643544. ISSN 0006-4971.