Acute promyelocytic leukemia epidemiology and demographics: Difference between revisions
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Acute promyelocytic leukemia is relatively rare compared to other [[Disease|diseases]]. It predominantly affects people of Latin American descent and least commonly affects African Americans. It is more common in older [[Adult|adults]]. | Acute promyelocytic leukemia is relatively rare compared to other [[Disease|diseases]]. It predominantly affects people of Latin American descent and least commonly affects African Americans. It is more common in older [[Adult|adults]]. | ||
==Epidemiology and | ==Epidemiology == | ||
==== Incidence ==== | |||
*Acute promyelocytic leukemia represents 10-15%% of all cases of acute myeloid leukemia in adults.<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref> | |||
*Acute promyelocytic leukemia affects approximately 1,500 people per year in the United States.<ref name="pmid24887205">{{cite journal| author=Kumar S, Yedjou CG, Tchounwou PB| title=Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. | journal=J Exp Clin Cancer Res | year= 2014 | volume= 33 | issue= | pages= 42 | pmid=24887205 | doi=10.1186/1756-9966-33-42 | pmc=4049373 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24887205 }} </ref> | |||
*The incidence of acute promyelocytic leukemia is 0.2 to 0.26 per 100,000 annually in the United States, which corresponds to 600-800 cases of acute promyelocytic leukemia per year.<ref name="pmid22707337">{{cite journal| author=Chen Y, Kantarjian H, Wang H, Cortes J, Ravandi F| title=Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008. | journal=Cancer | year= 2012 | volume= 118 | issue= 23 | pages= 5811-8 | pmid=22707337 | doi=10.1002/cncr.27623 | pmc=4180246 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22707337 }} </ref> | *The incidence of acute promyelocytic leukemia is 0.2 to 0.26 per 100,000 annually in the United States, which corresponds to 600-800 cases of acute promyelocytic leukemia per year.<ref name="pmid22707337">{{cite journal| author=Chen Y, Kantarjian H, Wang H, Cortes J, Ravandi F| title=Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008. | journal=Cancer | year= 2012 | volume= 118 | issue= 23 | pages= 5811-8 | pmid=22707337 | doi=10.1002/cncr.27623 | pmc=4180246 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22707337 }} </ref> | ||
* | *The incidence in Caucasians is 0.18 per 100,000. The incidence is African Americans is 0.14 per 100,000.<ref name="pmid22707337" /> | ||
* | *The [[incidence]] in men is 0.19 per 100,000, and the [[incidence]] in women is 0.17 per year.<ref name="pmid22707337" /> | ||
*The [[incidence]] of acute promyelocytic leukemia in people above age 60 is 0.36 per 100,000. | |||
*The [[incidence]] in people under age 20 is 0.06 per 100,000. | |||
*The incidence of acute promyelocytic leukemia has increased over time from 1975-2008.<ref name="pmid22707337" /> | |||
== Demographics == | |||
==== Race ==== | |||
*Caucasians are more commonly affected by acute promyelocytic leukemia than African Americans. | |||
*Asians and Pacific islanders are more commonly affected by acute promyelocytic leukemia than African Americans.<ref name="pmid22707337">{{cite journal| author=Chen Y, Kantarjian H, Wang H, Cortes J, Ravandi F| title=Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008. | journal=Cancer | year= 2012 | volume= 118 | issue= 23 | pages= 5811-8 | pmid=22707337 | doi=10.1002/cncr.27623 | pmc=4180246 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22707337 }} </ref> | *Asians and Pacific islanders are more commonly affected by acute promyelocytic leukemia than African Americans.<ref name="pmid22707337">{{cite journal| author=Chen Y, Kantarjian H, Wang H, Cortes J, Ravandi F| title=Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008. | journal=Cancer | year= 2012 | volume= 118 | issue= 23 | pages= 5811-8 | pmid=22707337 | doi=10.1002/cncr.27623 | pmc=4180246 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22707337 }} </ref> | ||
*The incidence is higher in people of Latin American descent compared to Caucasian descent.<ref name="pmid22707337" /> | *The incidence is higher in people of Latin American descent compared to Caucasian descent.<ref name="pmid22707337" /> | ||
*Men are more commonly affected by acute promyelocytic leukemia than women. | |||
*Older [[Patient|patients]] are more likely to develop acute promyelocytic leukemia than younger [[Patient|patients]] | === Gender === | ||
* | *Men are more commonly affected by acute promyelocytic leukemia than women. | ||
=== Age === | |||
*Older [[Patient|patients]] are more likely to develop acute promyelocytic leukemia than younger [[Patient|patients]]. | |||
*The median age is approximately 40 years, which is considerably younger than the other subtypes of [[acute myeloid leukemia]] (70 years). | |||
==References== | ==References== | ||
Revision as of 16:06, 6 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3]
Overview
Acute promyelocytic leukemia is relatively rare compared to other diseases. It predominantly affects people of Latin American descent and least commonly affects African Americans. It is more common in older adults.
Epidemiology
Incidence
- Acute promyelocytic leukemia represents 10-15%% of all cases of acute myeloid leukemia in adults.[1]
- Acute promyelocytic leukemia affects approximately 1,500 people per year in the United States.[2]
- The incidence of acute promyelocytic leukemia is 0.2 to 0.26 per 100,000 annually in the United States, which corresponds to 600-800 cases of acute promyelocytic leukemia per year.[3]
- The incidence in Caucasians is 0.18 per 100,000. The incidence is African Americans is 0.14 per 100,000.[3]
- The incidence in men is 0.19 per 100,000, and the incidence in women is 0.17 per year.[3]
- The incidence of acute promyelocytic leukemia in people above age 60 is 0.36 per 100,000.
- The incidence in people under age 20 is 0.06 per 100,000.
- The incidence of acute promyelocytic leukemia has increased over time from 1975-2008.[3]
Demographics
Race
- Caucasians are more commonly affected by acute promyelocytic leukemia than African Americans.
- Asians and Pacific islanders are more commonly affected by acute promyelocytic leukemia than African Americans.[3]
- The incidence is higher in people of Latin American descent compared to Caucasian descent.[3]
Gender
- Men are more commonly affected by acute promyelocytic leukemia than women.
Age
- Older patients are more likely to develop acute promyelocytic leukemia than younger patients.
- The median age is approximately 40 years, which is considerably younger than the other subtypes of acute myeloid leukemia (70 years).
References
- ↑ Chen C, Huang X, Wang K, Chen K, Gao D, Qian S (2018). "Early mortality in acute promyelocytic leukemia: Potential predictors". Oncol Lett. 15 (4): 4061–4069. doi:10.3892/ol.2018.7854. PMC 5835847. PMID 29541170.
- ↑ Kumar S, Yedjou CG, Tchounwou PB (2014). "Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells". J Exp Clin Cancer Res. 33: 42. doi:10.1186/1756-9966-33-42. PMC 4049373. PMID 24887205.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Chen Y, Kantarjian H, Wang H, Cortes J, Ravandi F (2012). "Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008". Cancer. 118 (23): 5811–8. doi:10.1002/cncr.27623. PMC 4180246. PMID 22707337.