Mycosis fungoides classification: Difference between revisions

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* May appear as a scaly, pink patches on the skin
* May appear as a scaly, pink patches on the skin
* Signs can progress to the development of skin tumors in more advanced cases
* Signs can progress to the development of skin tumors in more advanced cases
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| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Sézary syndrome'''  (SS) 
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* Often the more aggressive form of cutaneous T cell lymphoma
* An advanced form of mycosis fungoides
* Affects skin, blood, and lymph nodes
:* Large areas of the skin are affected
:* Skin is often red, itchy, painful, and peeling
:* Skin tumors can also appear
:* Entire body can be affected, also known as "red man syndrome"
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Revision as of 15:53, 6 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

There are 3 classification methods used to classify cutaneous T cell lymphoma into several subtypes. Cutaneous T cell lymphoma may be classified into several subtypes based on WHO-EORTC classification.

Classification

According to world Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classification, cutaneous T cell and NK cell lymphomas may be classified into the following types:[1][2]


Cutaneous T cell lymphoma classification[3]
Name Description
Mycosis fungoides (MF)
  • Most common form of cutaneous T cell lymphoma
  • Starts in the skin in areas of the body not usually exposed to the sun
  • May appear as a scaly, pink patches on the skin
  • Signs can progress to the development of skin tumors in more advanced cases
Cutaneous T cell lymphoma classification[4]
Name Description
Primary or cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
  • Characterized by localized or disseminated eruptive papules, nodules with tumors showing central ulceration, and necrosis or by superficial hyperkeratotic patches and plaques
  • Dissemination to other visceral sites (lung, testis, CNS, and oral mucosa)
  • Lymph nodes are seldom affected
  • Aggressive clinical course with median survival rate of 32 months
Primary cutaneous CD4-positive small/medium T-cell lymphoma
  • Clinical presentation is usually a solitary plaque or nodule, commonly on the face, neck, or upper trunk
  • The involvement of lower extremities is rare
  • Cutaneous patches are generally absent

References

  1. ↑ Matutes, E. (2018). "The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms". International Journal of Laboratory Hematology. 40: 97–103. doi:10.1111/ijlh.12817. ISSN 1751-5521.
  2. ↑ Sundram, Uma (2018). "Cutaneous Lymphoproliferative Disorders". Advances In Anatomic Pathology: 1. doi:10.1097/PAP.0000000000000208. ISSN 1072-4109.
  3. ↑ Cutaneous T cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/cutaneous-t-cell-lymphoma/?region=on Accessed on January 19, 2016
  4. ↑ Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016


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