Acute lymphoblastic leukemia diagnostic study of choice: Difference between revisions
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*A bone marrow biopsy must show 20% or greater blasts of lymphoid immunophenotype<ref name="pmid25408859">{{cite journal| author=Chiaretti S, Zini G, Bassan R| title=Diagnosis and subclassification of acute lymphoblastic leukemia. | journal=Mediterr J Hematol Infect Dis | year= 2014 | volume= 6 | issue= 1 | pages= e2014073 | pmid=25408859 | doi=10.4084/MJHID.2014.073 | pmc=4235437 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25408859 }} </ref> | *A bone marrow biopsy must show 20% or greater blasts of lymphoid immunophenotype<ref name="pmid25408859">{{cite journal| author=Chiaretti S, Zini G, Bassan R| title=Diagnosis and subclassification of acute lymphoblastic leukemia. | journal=Mediterr J Hematol Infect Dis | year= 2014 | volume= 6 | issue= 1 | pages= e2014073 | pmid=25408859 | doi=10.4084/MJHID.2014.073 | pmc=4235437 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25408859 }} </ref> | ||
*This diagnostic criteria is very similar to that of acute myeloid leukemia.<ref name="pmid28665419">{{cite journal| author=Terwilliger T, Abdul-Hay M| title=Acute lymphoblastic leukemia: a comprehensive review and 2017 update. | journal=Blood Cancer J | year= 2017 | volume= 7 | issue= 6 | pages= e577 | pmid=28665419 | doi=10.1038/bcj.2017.53 | pmc=5520400 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28665419 }} </ref> | *This diagnostic criteria is very similar to that of acute myeloid leukemia.<ref name="pmid28665419">{{cite journal| author=Terwilliger T, Abdul-Hay M| title=Acute lymphoblastic leukemia: a comprehensive review and 2017 update. | journal=Blood Cancer J | year= 2017 | volume= 7 | issue= 6 | pages= e577 | pmid=28665419 | doi=10.1038/bcj.2017.53 | pmc=5520400 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28665419 }} </ref> | ||
===== Diagnostic results ===== | |||
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]: | |||
*Lymphoblast | |||
===== Sequence of Diagnostic Studies ===== | |||
The various investigations must be performed in the following order: | |||
*CBC | |||
*Histopathological microscopy | |||
*Bone marrow biopsy | |||
*Flow cytometry | |||
*Immunohistochemistry | |||
*PCR | |||
*FISH | |||
==References== | ==References== | ||
Revision as of 20:06, 29 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Shyam Patel [2]
Overview
The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy.
Diagnostic study of choice
- The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy
- A bone marrow biopsy must show 20% or greater blasts of lymphoid immunophenotype[1]
- This diagnostic criteria is very similar to that of acute myeloid leukemia.[2]
Diagnostic results
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
- Lymphoblast
Sequence of Diagnostic Studies
The various investigations must be performed in the following order:
- CBC
- Histopathological microscopy
- Bone marrow biopsy
- Flow cytometry
- Immunohistochemistry
- PCR
- FISH
References
- ↑ Chiaretti S, Zini G, Bassan R (2014). "Diagnosis and subclassification of acute lymphoblastic leukemia". Mediterr J Hematol Infect Dis. 6 (1): e2014073. doi:10.4084/MJHID.2014.073. PMC 4235437. PMID 25408859.
- ↑ Terwilliger T, Abdul-Hay M (2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.