Acute lymphoblastic leukemia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include:<ref name="pmid25408859">{{cite journal |vauthors=Chiaretti S, Zini G, Bassan R |title=Diagnosis and subclassification of acute lymphoblastic leukemia |journal=Mediterr J Hematol Infect Dis |volume=6 |issue=1 |pages=e2014073 |date=2014 |pmid=25408859 |pmc=4235437 |doi=10.4084/MJHID.2014.073 |url=}}</ref> | Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include:<ref name="pmid25408859">{{cite journal |vauthors=Chiaretti S, Zini G, Bassan R |title=Diagnosis and subclassification of acute lymphoblastic leukemia |journal=Mediterr J Hematol Infect Dis |volume=6 |issue=1 |pages=e2014073 |date=2014 |pmid=25408859 |pmc=4235437 |doi=10.4084/MJHID.2014.073 |url=}}</ref> | ||
* [[Anemia]] | * [[Anemia]]<ref name="pmid22543829">{{cite journal| author=Steele M, Narendran A| title=Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL). | journal=Ann Hematol | year= 2012 | volume= 91 | issue= 10 | pages= 1513-8 | pmid=22543829 | doi=10.1007/s00277-012-1475-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22543829 }} </ref> | ||
* [[Lymphocytosis]] | * [[Lymphocytosis]] | ||
* [[Thrombocytopenia]]<ref name="pmid2587136">{{cite journal| author=Dubansky AS, Boyett JM, Falletta J, Mahoney DH, Land VJ, Pullen J et al.| title=Isolated thrombocytopenia in children with acute lymphoblastic leukemia: a rare event in a Pediatric Oncology Group Study. | journal=Pediatrics | year= 1989 | volume= 84 | issue= 6 | pages= 1068-71 | pmid=2587136 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2587136 }} </ref> | * [[Thrombocytopenia]]<ref name="pmid2587136">{{cite journal| author=Dubansky AS, Boyett JM, Falletta J, Mahoney DH, Land VJ, Pullen J et al.| title=Isolated thrombocytopenia in children with acute lymphoblastic leukemia: a rare event in a Pediatric Oncology Group Study. | journal=Pediatrics | year= 1989 | volume= 84 | issue= 6 | pages= 1068-71 | pmid=2587136 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2587136 }} </ref> | ||
Revision as of 19:20, 30 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [5] Carlos A Lopez, M.D. [6]
Ovierview
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include eosinophilia, lymphocytosis, red cell production reduced, thrombocytopenia. Chemistry panels with altered levels of uric acid, creatinine, blood urea nitrogen, potassium, phosphate, calcium, bilirubin, hepatic transaminases and ferritin.
Laboratory Findings
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include:[1]
- Anemia[2]
- Lymphocytosis
- Thrombocytopenia[3]
- Eosinophilia[4]
- A chemistry panel may also demonstrate altered concentrations of the following:[5]
- A spinal tap is often required to evaluate for central nervous system involvement.
![[1]](https://commons.wikimedia.org/wiki/Category:Acute_lymphoblastic_leukemia#/media/File:ALL-L1.jpg){kind=link}
![[2]](https://commons.wikimedia.org/wiki/File:ALL-KM-2.jpg){kind=link}
![[3]](https://commons.wikimedia.org/wiki/File:ALL-KM-3.jpg){kind=link}
References
- ↑ Chiaretti S, Zini G, Bassan R (2014). "Diagnosis and subclassification of acute lymphoblastic leukemia". Mediterr J Hematol Infect Dis. 6 (1): e2014073. doi:10.4084/MJHID.2014.073. PMC 4235437. PMID 25408859.
- ↑ Steele M, Narendran A (2012). "Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL)". Ann Hematol. 91 (10): 1513–8. doi:10.1007/s00277-012-1475-5. PMID 22543829.
- ↑ Dubansky AS, Boyett JM, Falletta J, Mahoney DH, Land VJ, Pullen J; et al. (1989). "Isolated thrombocytopenia in children with acute lymphoblastic leukemia: a rare event in a Pediatric Oncology Group Study". Pediatrics. 84 (6): 1068–71. PMID 2587136.
- ↑ Rezamand A, Ghorashi Z, Ghorashi S, Nezami N (2013). "Eosinophilic presentation of acute lymphoblastic leukemia". Am J Case Rep. 14: 143–6. doi:10.12659/AJCR.883905. PMC 3715333. PMID 23869247.
- ↑ "National Cancer Institute".