Sandbox:Roukoz

Diseases	Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
	Symptoms			Physical examination
							Lab Findings			Imaging			Histopathology
	Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3
Cutaneous squamous cell carcinoma	pain	erythema		indurated	hyperkeratotic	increased size								skin biopsy	60 percent of squamous cell carcinomas occur at the site of a previous actinic keratosis
Merkel cell carcinoma				Starts on areas of skin exposed to the sun	Single pink, red, or purple shiny bump	Painless								Skin biopsy	blue-red, dome-shaped nodule
Nodular malignant melanoma				Lump that has been rapidly growing over the past weeks									Cells proliferate downwards through the skin (vertical growth)	Skin biopsy	Two-thirds arise in normal skin, the rest in existing moles Genetic component in some cases with a positive family history
Amelanotic melanoma				Color usually pink, purple or normal skin color	Usually have an asymmetrical shape with an irregular border	red, nonspecific lesion with slightly elevated borders								skin biopsy	Do not make melanin, so lesions are not pigmented
Basal cell carcinoma				Coarse scale lesion										Skin biopsy
Superficial basal cell carcinoma				scaly patch	erythematous lesion								large, hyperchromatic, oval nuclei and little cytoplasm well differentiated and cells appear histologically similar to basal cells of the epidermis	skin biopsy
Nodular basal cell carcinoma				Pearly papule with telangiectasias										Skin biopsy
Cutaneous metastases of internal malignancy
Benign Skin Lesions
Sebaceous cell carcinoma				Yellow-nodule											Suspected due to evidence of eyelash loss
Rhabdomyosarcoma	Bulging of the eye or a swollen eyelid														Develops in skeletal muscles usually
Actinic keratoses	pain			hyperkeratosis	erythema	less pigmentation, and tend to be somewhat smaller in size.								Skin biopsy
Prurigo nodules	Hard lesion	Itchy lumps
Paget disease				Eczema-like rash of the skin	Around the genital regions of males and females.								Similar to mammary paget disease		chronic
Inflamed seborrheic keratosis				waxy, "stuck on," often hyperkeratotic appearance						On dermatoscopic evaluation, presence of horned cysts and hairpin-shaped blood vessels				Skin biopsy
Viral warts				Verrucous lesion											Caused by HPV
Pyogenic granuloma				Rapidly growing	Red, dome-shaped	Friable papule with a collarette of scale
Bowenoid papulosis				multiple, red- to brown-colored, small papules that											primarily arise on genitals induced by human papillomavirus (HPV) infection
Nummular eczema	Itchy lesions			Coin shaped spots											Chronic condition
Psoriasis	Flaking, inflammation			Thick, white, silvery, or red patches of skin											Chronic condition
Pyoderma gangrenosum				Purulent ulcer	Ragged and violaceous border
Venous stasis ulcers
Traumatic ulcers
Bowen Disease				Red scaly patch											Very early form of skin cancer that is very treatable referred to as squamous cell carcinoma insitu
Sebaceous Hyperplasia				Lesions can be single or multiple lesions	Yellowish, soft, small papules on the face	Usually on the nose, cheeks, and forehead
Allergic Contact Dermatitis	Itchy rash			Red rash											Not contagious
Atopic Dermatitis	Itchy rash	Fever		Red rash											Chronic and sometimes accompanied by asthma
Atypical Fibroxanthoma				Erythematous, dome-shaped papule
Nevus
Chemical Burns
Limbal Dermoid													Contains choristomatous tissue		Benign congenital tumor
Benign hereditary intraepithelial dyskeratosis															Rare autosomal-dominant disorder of the conjunctiva and oral mucosa
primary acquired melanosis
Fibrous xanthoma													Containing fibromatous elements		Arises due to disturbed systemic lipid metabolism
Inflamed seborrheic keratosis				Inflamed and hyperpigmented
Juvenile xanthogranuloma				Reddened, yellowish-tan color of lesions	Slightly raised bumps										Typically
Cutaneous fungal infections
Desmoplastic trichoepithelioma
Adnexal carcinoma															Very rare
Keratoacanthoma
Darier disease															Keratosis follicularis
Cutaneous T-cell lymphoma															Mycosis fungoides
Marjolin's ulcer				Lesions in sites of chronic wounds and scars	Excessive granulation tissue,	Rolled or everted wound margins	Bleeding on touch								rare type of SCC Very slow malignant transformation
Cutaneous T-cell lymphoma															Mycosis fungoides
Cutaneous T-cell lymphoma															Mycosis fungoides
Cutaneous T-cell lymphoma															Mycosis fungoides