Cancer of unknown primary origin pathophysiology: Difference between revisions

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Revision as of 20:52, 6 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

The exact pathogenesis of cancer of unknown primary origin is not fully understood.

Pathophysiology

Physiology

The normal physiology of [name of process] can be understood as follows:

Pathogenesis

The exact pathogenesis of cancer of unknown primary origin is not fully understood.
Cancer of unknown primary, like other cancers, arises from one cell that has managed to escape regulation and produces a tumor at a certain site (the site of origin) and consequently metastasizes to other parts of the body.
It is thought that the site of origin of CUP remains unknown due to one of the following theories:^[1]
- Remaining small and undetectable clinically
- Disappearing after metastasizing
- Elimination by body's defense

It remains unknown whether cancers of unknown primaries are genetically or phenotypically distinct from metastasis with known origins.^[1]

References

↑ ^1.0 ^1.1 Varadhachary GR (2007). "Carcinoma of unknown primary origin". Gastrointest Cancer Res. 1 (6): 229–35. PMC 2631214. PMID 19262901.

Template:WH Template:WS

[pmid19262901-1] 1.0 ^1.1 Varadhachary GR (2007). "Carcinoma of unknown primary origin". Gastrointest Cancer Res. 1 (6): 229–35. PMC 2631214. PMID 19262901.

[1]

@@ Line 4: / Line 4: @@
 {{CMG}}; {{AE}}
 ==Overview==
-The exact pathogenesis of [disease name] is not fully understood.
+The exact [[pathogenesis]] of cancer of unknown primary origin is not fully understood.
-OR
-It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
-OR
-[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
-OR
-Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
-OR
-[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
-OR
-The progression to [disease name] usually involves the [molecular pathway].
-OR
-The pathophysiology of [disease/malignancy] depends on the histological subtype.
 ==Pathophysiology==
@@ Line 44: / Line 19: @@
 * It remains unknown whether cancers of unknown primaries are [[genetically]] or [[phenotypically]] distinct from [[metastasis]] with known origins.<ref name="pmid19262901">{{cite journal |vauthors=Varadhachary GR |title=Carcinoma of unknown primary origin |journal=Gastrointest Cancer Res |volume=1 |issue=6 |pages=229–35 |year=2007 |pmid=19262901 |pmc=2631214 |doi= |url=}}</ref>
-*The exact pathogenesis of [disease name] is not completely understood.
-OR
-*It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
-*[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
-*Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
-*[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
-*The progression to [disease name] usually involves the [molecular pathway].
-*The pathophysiology of [disease/malignancy] depends on the histological subtype.
-==Genetics==
-[Disease name] is transmitted in [mode of genetic transmission] pattern.
-OR
-Genes involved in the pathogenesis of [disease name] include:
-*[Gene1]
-*[Gene2]
-*[Gene3]
-OR
-The development of [disease name] is the result of multiple genetic mutations such as:
-*[Mutation 1]
-*[Mutation 2]
-*[Mutation 3]
-==Associated Conditions==
-Conditions associated with [disease name] include:
-*[Condition 1]
-*[Condition 2]
-*[Condition 3]
-==Gross Pathology==
-On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
-==Microscopic Pathology==
-On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
 ==References==