Waldenström's macroglobulinemia

Waldenström's macroglobulinemia Microchapters
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Diagnostic Study of Choice
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Case Studies
Case #1
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For patient information on this page, click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Roukoz A. Karam, M.D.[3], Mirdula Sharma, MBBS [4]

Synonyms and keywords: Waldenstrom/Waldenstrom's macroglubulinemia (WM), Primary macroglobulinemia, Lymphoplasmacytic lymphoma (LPL), Plasmacytoid lymphocytic lymphoma, Familial Waldenstrom's Macroglobulinaemia, Waldenström macroglobulinaemia

Diagnostic criteria of Waldenstrom Macroglobulinemia

In September 26-30, 2002, in Athens, Greece,the Second International Workshop was held in which the following diagnostic criteria for Waldenstrom's Macroglobulinemia was proposed:

1. IgM monoclonal protein of any concentration.
2. Bone marrow infiltration by small lymphocytes showing plasmacytoid/plasma-cell differentiation.
3. Intertrabecular pattern of bone marrow infiltration.
4. Surface IgM+, CD5±, CD10−, CD19+, CD20+, CD22+, CD23−, CD25+, CD27+, FMC7+, CD103−, CD138 immunophenotype.

(3,4 are supportive of but not necessary for WM diagnosis).

• Not all the diagnostic tests mentioned are performed in a WM patient. A doctor takes into account the following factors before choosing diagnostic tests in a particular patient:
  • Suspected type of cancer.
  • Signs and symptoms.
  • Age.
  • Medical condition of the patient.
  • Results of earlier medical tests.

Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Electrocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1