Ovarian cancer differential diagnosis: Difference between revisions
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* In some cases we may see elevated levels of CA 125 lactate dehydrogenase | * In some cases we may see elevated levels of [[CA-125]] [[lactate dehydrogenase]] | ||
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* Heterogeneous mass with central low attenuation (necrosis) and calcification. | * Heterogeneous mass with central low attenuation ([[necrosis]]) and [[calcification]]. | ||
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* Increased uterine size | * Increased [[uterine]] size | ||
* Irregular central zones of low signal intensity (tumor necrosis) | * Irregular central zones of low signal intensity (tumor [[necrosis]]) | ||
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* We may see atypical cells, high mitotic rate, geographic areas of coagulative necrosis separated from viable neoplasm | * We may see [[Atypia|atypical cells]], high [[mitotic]] rate, geographic areas of [[coagulative necrosis]] separated from viable [[neoplasm]] | ||
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* Biopsy | * [[Biopsy]] | ||
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* In case of rapid uterine growth in post menopausal women we may suspect uterine sarcoma | * In case of rapid [[uterine]] growth in post [[Menopause|menopausal]] [[women]] we may suspect [[uterine sarcoma]] | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pregnancy]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pregnancy]] | ||
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* Women in reproductive age (15 -45 y/o) | * [[Women]] in [[reproductive]] age (15 -45 y/o) | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | +/− | | style="background: #F5F5F5; padding: 5px; text-align: center;" | +/− | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | +/− | | style="background: #F5F5F5; padding: 5px; text-align: center;" | +/− | ||
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* High level of BhCG | * High level of [[HCG|BhCG]] | ||
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* In US we may see | * In [[Ultrasound|US]] we may see [[gestational sac]], [[yolk sac]], double bleb sign and [[fetal]] pore | ||
* In CT scan we may see cystic structure filled with fluid, curvilinear enhancing structure (placenta) and fetal pore | * In [[CT scan]] we may see [[cystic]] structure filled with fluid, curvilinear enhancing structure ([[placenta]]) and [[fetal]] pore | ||
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* Cystic structure filled with fluid | * [[Cystic]] structure filled with fluid | ||
* Curvilinear enhancing structure (placenta) | * Curvilinear enhancing structure ([[placenta]]) | ||
* Fetal pore | * [[Fetal]] pore | ||
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* NA | * NA | ||
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* History/laboratory findings | * [[History and Physical examination|History]]/[[laboratory]] findings | ||
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* We do not perform CT scan and MRI in pregnancy but We may unintentionally image the pregnancy with CT scan and MRI. | * We do not perform [[CT scan]] and [[MRI]] in [[pregnancy]] but We may unintentionally image the [[pregnancy]] with [[CT scan]] and [[MRI]]. | ||
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! colspan="15" style="background: #7d7d7d; color: #FFFFFF; text-align: center;" |Non-gynecologic | ! colspan="15" style="background: #7d7d7d; color: #FFFFFF; text-align: center;" |Non-gynecologic |
Revision as of 16:48, 7 February 2019
Ovarian cancer Microchapters |
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Ovarian cancer differential diagnosis On the Web |
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Risk calculators and risk factors for Ovarian cancer differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
Differentiating [Disease name] from other Diseases
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | ||||||||||
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Age of onset | Symptoms | Physical examination | ||||||||||||
Lab Findings | Imaging | Immunohistopathology | ||||||||||||
pelvic/abdominal pain or pressure | vaginal bleeding/discharge | GI dysturbance | Pleural effusion | Fever | Tenderness | CT scan/US | MRI | |||||||
Gynecologic | ||||||||||||||
Ovarian | Follicular cysts | – |
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Theca lutein cysts | – |
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Serous cystadenoma/carcinoma |
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– |
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Mucinous cystadenoma/carcinoma |
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– |
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Endometrioma |
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+ | + | +/– | – | – | + |
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Teratoma |
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+/– | – | – | – | – | +/– |
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Dysgerminoma |
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+ | +/– | – | – | – | +/– |
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Yolk sac tumor |
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+ | – | – | – | – | + |
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Fibroma |
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– | – | +/– | – | +/– |
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Thecoma |
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+/– |
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– | – | – | – |
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Granulosa cell tumor |
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+ |
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+/– | – | – | – |
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Sertoli-leydig cell tumor |
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+/– | – | – | – | – | – |
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Brenner tumor |
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+/– | – | – | – | – | – | – |
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Krukenberg tumor |
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+/– | – | +/–
Based on underlying malignancy |
+/–
Based on underlying malignancy |
– | – |
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Imaging/biopsy |
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Tubal | tubo-ovarian abscess |
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+ | + | – | – | + | + |
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Ectopic pregnancy |
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+ | + | +/– | – | – | + |
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Hydrosalpinx |
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+ | – | – | – | – | +/– | – |
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Salpingitis |
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+ | + | – | – | + | + |
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Fallopian tube carcinoma |
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+ | + | + | + | – | +/– |
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Uterine | Leiomyoma |
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+ | + | – | – | – | +/– |
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Choriocarcinoma |
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+ | + | +/– | – | – | + |
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Leiomyosarcoma |
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+ | + | – | – | – | +/– |
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Pregnancy |
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+/− | +/− | +/− | – | – | – |
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Non-gynecologic | ||||||||||||||
GIT | Appendiceal abscess |
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+ | – | + | + | +/– | + |
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Appendiceal neoplasm[1] |
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+ | – | + | + | – | +/– |
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Diverticular abscess |
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+ | – | + | + | +/– | + |
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Colorectal cancer |
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+ | – | + | – | – | +/– |
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Renal | Pelvic kidney |
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−/+
In case of sever hydronephrosis or renal stone we may have pelvic pain |
– | − | − | − | − | − |
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Bladder cancer |
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+ | – | – | – | – | – |
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Others | Retroperitoneal sarcoma[2] |
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+ | – | + | − | − | − |
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check sites of cancer that may metastasize to the ovaries (eg, stomach, colorectal, breast)
check rectum, liver, spleen, lungs, inguinal or supraclavicular lymph nodes for ovary metastase
- Bladder tumour–associated antigen (BTA)
- Nuclear matrix proteins (NMP)
- Mucin and carcinoembryonic antigen (CEA)
References
- ↑ Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019
- ↑ Storm FK, Mahvi DM (July 1991). "Diagnosis and management of retroperitoneal soft-tissue sarcoma". Ann. Surg. 214 (1): 2–10. PMC 1358407. PMID 2064467.