Waldenström's macroglobulinemia bone marrow aspiration and biopsy: Difference between revisions
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* A hypercellular bone marrow aspirate. | * A hypercellular bone marrow aspirate. | ||
* Lymphoplasmacytic infiltrate with characteristic immunophenotype. | * Lymphoplasmacytic infiltrate with characteristic immunophenotype. | ||
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[[File:Wm bm aspirate.png|thumb|250px|none| Bone marrow aspirate. Lymphocytes with lymphoplasmacytoid appearance (arrows).[https://openi.nlm.nih.gov/detailedresult.php?img=PMC3894394_br-48-300-g001&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=91 Source: D'Angelo G. et al, Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Varese, Italy.]]] | |||
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== Bone Marrow Biopsy == | == Bone Marrow Biopsy == | ||
Revision as of 02:31, 16 February 2019
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Waldenström's macroglobulinemia bone marrow aspiration and biopsy On the Web |
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Directions to Hospitals Treating Waldenström's macroglobulinemia |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Roukoz A. Karam, M.D.[3]
Overview
A bone marrow aspiration is essential in the diagnosis of Waldenström macroglobulinemia.
Bone Marrow Aspirate
A bone marrow aspirate is essential in the diagnosis of Waldenström macroglobulinemia.
Findings suggestive of Waldenström macroglobulinemia include:[1]
- A hypercellular bone marrow aspirate.
- Lymphoplasmacytic infiltrate with characteristic immunophenotype.
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Bone Marrow Biopsy
A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia. [1]
Findings on the biopsy suggestive of Waldenström macroglobulinemia include:[1]
- Hypercellular and infiltrated with lymphoid and plasmacytoid cells.
- Dutcher bodies (PAS positive intra-nuclear vacuoles containing IgM monoclonal protein).
- Characteristic feature of Waldenström macroglobulinemia.
Three patterns of marrow involvement are described, as follows:
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern.
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern.
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures).
References
- ↑ 1.0 1.1 1.2 Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J; et al. (2008). "Waldenstrom macroglobulinemia". Cancer Lett. 270 (1): 95–107. doi:10.1016/j.canlet.2008.04.040. PMC 3133633. PMID 18555588.