Ovarian cancer differential diagnosis: Difference between revisions
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* NA | * NA | ||
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* History/imaging | |||
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* It is associated with hyperestrogenism and endometrial hyperplasia | * It is associated with hyperestrogenism and endometrial hyperplasia | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Ovarian cyst|Theca lutein cysts]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Ovarian cyst|Theca lutein cysts]] | ||
| style="background: #F5F5F5; padding: 5px;" |Women in reproductive age (15 -45 y/o) | | style="background: #F5F5F5; padding: 5px;" | | ||
* Women in reproductive age (15 -45 y/o) | |||
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* It is associated with hydatidiform moles and | * It is associated with hydatidiform moles, choriocarcinoma, diabetes mellitus and clomiphene intake (ovulation induction) | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |Serous cystadenoma/carcinoma | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Serous cystadenoma/carcinoma | ||
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* Mucin-secreting signet cell | * Mucin-secreting signet cell | ||
| style="background: #F5F5F5; padding: 5px;" |Imaging/biopsy | | style="background: #F5F5F5; padding: 5px;" | | ||
* Imaging/biopsy | |||
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* The most common primary tumor is in colon, stomach, breast, lung, and contralateral ovary. | * The most common primary tumor is in colon, stomach, breast, lung, and contralateral ovary. |
Revision as of 16:20, 8 February 2019
Ovarian cancer Microchapters |
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Ovarian cancer differential diagnosis On the Web |
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Risk calculators and risk factors for Ovarian cancer differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
Differentiating [Disease name] from other Diseases
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age of onset | Symptoms | Physical examination | ||||||||||||
Lab Findings | Imaging | Immunohistopathology | ||||||||||||
pelvic/abdominal pain or pressure | vaginal bleeding/discharge | GI dysturbance | Pleural effusion | Fever | Tenderness | CT scan/US | MRI | |||||||
Gynecologic | ||||||||||||||
Ovarian | Follicular cysts |
|
+/– | – | – | – | – | – |
|
|
| |||
Theca lutein cysts |
|
– |
|
|
| |||||||||
Serous cystadenoma/carcinoma |
|
– |
|
| ||||||||||
Mucinous cystadenoma/carcinoma |
|
– |
| |||||||||||
Endometrioma |
|
+ | + | +/– | – | – | + |
|
|
|
|
|
| |
Teratoma |
|
+/– | – | – | – | – | +/– |
|
|
|
|
|
| |
Dysgerminoma |
|
+ | +/– | – | – | – | +/– |
|
|
|
|
|
| |
Yolk sac tumor |
|
+ | – | – | – | – | + |
|
|
|
|
|
| |
Fibroma |
|
|
– | – | +/– | – | +/– |
|
|
|
|
|
| |
Thecoma |
|
+/– |
|
– | – | – | – |
|
|
|
|
|
| |
Granulosa cell tumor |
|
+ |
|
+/– | – | – | – |
|
|
|
|
|
| |
Sertoli-leydig cell tumor |
|
+/– | – | – | – | – | – |
|
|
|
|
|
| |
Brenner tumor |
|
+/– | – | – | – | – | – | – |
|
|
|
|
| |
Krukenberg tumor |
|
+/– | – | +/–
Based on underlying malignancy |
+/–
Based on underlying malignancy |
– | – |
|
|
|
|
|
| |
Tubal | tubo-ovarian abscess |
|
+ | + | – | – | + | + |
|
|
|
|
|
|
Ectopic pregnancy |
|
+ | + | +/– | – | – | + |
|
|
|
|
|
| |
Hydrosalpinx |
|
+ | – | – | – | – | +/– | – |
|
|
|
|
| |
Salpingitis |
|
+ | + | – | – | + | + |
|
|
|
|
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| |
Fallopian tube carcinoma |
|
+ | + | + | + | – | +/– |
|
|
|
|
|
| |
Uterine | Leiomyoma |
|
+ | + | – | – | – | +/– |
|
|
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|
Choriocarcinoma |
|
+ | + | +/– | – | – | + |
|
|
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| |
Leiomyosarcoma |
|
+ | + | – | – | – | +/– |
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|
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| |||
Pregnancy |
|
+/− | +/− | +/− | – | – | – |
|
|
|
||||
Non-gynecologic | ||||||||||||||
GIT | Appendiceal abscess |
|
+ | – | + | + | +/– | + |
|
|
|
| ||
Appendiceal neoplasm[1] |
|
+ | – | + | + | – | +/– |
|
|
|
|
| ||
Diverticular abscess |
|
+ | – | + | + | +/– | + |
|
|
|
| |||
Colorectal cancer |
|
+ | – | + | – | – | +/– |
|
|
|
|
| ||
Renal | Pelvic kidney |
|
−/+
In case of sever hydronephrosis or renal stone we may have pelvic pain |
– | − | − | − | − | − |
|
|
|
| |
Bladder cancer |
|
+ | – | – | – | – | – |
|
|
|
|
| ||
Others | Retroperitoneal sarcoma[2] |
|
+ | – | + | − | − | − |
|
|
|
|
|
check sites of cancer that may metastasize to the ovaries (eg, stomach, colorectal, breast)
check rectum, liver, spleen, lungs, inguinal or supraclavicular lymph nodes for ovary metastase
- Bladder tumour–associated antigen (BTA)
- Nuclear matrix proteins (NMP)
- Mucin and carcinoembryonic antigen (CEA)
References
- ↑ Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019
- ↑ Storm FK, Mahvi DM (July 1991). "Diagnosis and management of retroperitoneal soft-tissue sarcoma". Ann. Surg. 214 (1): 2–10. PMC 1358407. PMID 2064467.