Fibroadenoma historical perspective: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
* In 1994, Dupont et al addressed in their retrospective cohort study that fibroadenoma is associated with a long term risk of invasive breast cancer, with the risk further increased in women with complex fibroadenomas, a family history of breast cancer and those with proliferative disease. Later in a study with Carter, they found that the presence of atypic within a fibroadenoma cannot foretell the presence of one in the adjacent breast parenchyma. They also found that atypia within a fibroadenoma does not present a relevant risk of development of breast cancer greater than that of a fibroadenoma with no atypia within.<ref name="pmid8202095">{{cite journal| author=Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD, Rados MS et al.| title=Long-term risk of breast cancer in women with fibroadenoma. | journal=N Engl J Med | year= 1994 | volume= 331 | issue= 1 | pages= 10-5 | pmid=8202095 | doi=10.1056/NEJM199407073310103 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8202095 }} </ref><ref name="pmid11443606">{{cite journal| author=Carter BA, Page DL, Schuyler P, Parl FF, Simpson JF, Jensen RA et al.| title=No elevation in long-term breast carcinoma risk for women with fibroadenomas that contain atypical hyperplasia. | journal=Cancer | year= 2001 | volume= 92 | issue= 1 | pages= 30-6 | pmid=11443606 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11443606 }} </ref> | * In 1994, Dupont et al addressed in their retrospective cohort study that fibroadenoma is associated with a long term risk of invasive breast cancer, with the risk further increased in women with complex fibroadenomas, a family history of breast cancer and those with proliferative disease. Later in a study with Carter, they found that the presence of atypic within a fibroadenoma cannot foretell the presence of one in the adjacent breast parenchyma. They also found that atypia within a fibroadenoma does not present a relevant risk of development of breast cancer greater than that of a fibroadenoma with no atypia within.<ref name="pmid8202095">{{cite journal| author=Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD, Rados MS et al.| title=Long-term risk of breast cancer in women with fibroadenoma. | journal=N Engl J Med | year= 1994 | volume= 331 | issue= 1 | pages= 10-5 | pmid=8202095 | doi=10.1056/NEJM199407073310103 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8202095 }} </ref><ref name="pmid11443606">{{cite journal| author=Carter BA, Page DL, Schuyler P, Parl FF, Simpson JF, Jensen RA et al.| title=No elevation in long-term breast carcinoma risk for women with fibroadenomas that contain atypical hyperplasia. | journal=Cancer | year= 2001 | volume= 92 | issue= 1 | pages= 30-6 | pmid=11443606 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11443606 }} </ref> | ||
* In 2008, Solar-Levy et al reported the presence of invasive lobular carcinoma in about 1.6% of patients with complex fibroadenomas and advised that any complex fibroadenoma with a high risk lesion on core biopsy should be excised. | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Historical Perspective
- In 1994, Dupont et al addressed in their retrospective cohort study that fibroadenoma is associated with a long term risk of invasive breast cancer, with the risk further increased in women with complex fibroadenomas, a family history of breast cancer and those with proliferative disease. Later in a study with Carter, they found that the presence of atypic within a fibroadenoma cannot foretell the presence of one in the adjacent breast parenchyma. They also found that atypia within a fibroadenoma does not present a relevant risk of development of breast cancer greater than that of a fibroadenoma with no atypia within.[1][2]
- In 2008, Solar-Levy et al reported the presence of invasive lobular carcinoma in about 1.6% of patients with complex fibroadenomas and advised that any complex fibroadenoma with a high risk lesion on core biopsy should be excised.
References
- ↑ Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD, Rados MS; et al. (1994). "Long-term risk of breast cancer in women with fibroadenoma". N Engl J Med. 331 (1): 10–5. doi:10.1056/NEJM199407073310103. PMID 8202095.
- ↑ Carter BA, Page DL, Schuyler P, Parl FF, Simpson JF, Jensen RA; et al. (2001). "No elevation in long-term breast carcinoma risk for women with fibroadenomas that contain atypical hyperplasia". Cancer. 92 (1): 30–6. PMID 11443606.