Mycosis fungoides history and symptoms: Difference between revisions
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| colspan="3" |'''Histopathologic''' | | colspan="3" ! style="background: #4479BA; color:#FFF;" |'''Histopathologic''' | ||
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|Superficial lymphoid infiltrate plus | |Superficial lymphoid infiltrate plus | ||
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| colspan="3" |'''Molecular/biological''' | | colspan="3" ! style="background: #4479BA; color:#FFF;" |'''Molecular/biological''' | ||
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|2. Atypia | |2. Atypia | ||
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|Present | |Present | ||
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|'''Immunopathologic''' | | colspan="3" ! style="background: #4479BA; color:#FFF;" |'''Immunopathologic''' | ||
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Revision as of 05:59, 11 February 2019
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Mycosis fungoides Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Mycosis fungoides history and symptoms On the Web |
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American Roentgen Ray Society Images of Mycosis fungoides history and symptoms |
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Risk calculators and risk factors for Mycosis fungoides history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
The most common symptoms of mycosis fungoides include fever, weight loss, skin rash, night sweats, itching, chest pain, abdominal pain, and bone pain.[1]
History and Symptoms
History
- The majority of patients with mycosis fungoides is present with:[2]
- Skin patches and plaques
- Skin erythema with or without exfoliation
- Erythroderma observed patchy or diffuse[3]
- Erythroderma observed with cracking or fissuring of the palms and soles.[3]
- Eczema
- Psoriasis
- Other benign skin disorders
- Patients with advanced disease may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
- Skin lesions in the disease obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
- Tumors
- > 1 cm in size (depth or vertical growth)
Diagnosis criteria from the International Society for Cutaneous Lymphoma is:[2][4]
| Criteria | Major( 2pinots) | Minor(1point) | ||
|---|---|---|---|---|
| Persistent and/or progressive patches and plaques plus | Any 2 | Any 1 | ||
| 1. Non–sun-exposed location | ||||
| 2.Size/shape variation | ||||
| 3.Poikiloderma | ||||
| Histopathologic | ||||
| Superficial lymphoid infiltrate plus | Both | Either | ||
| 1. Epidermotropism | ||||
| Molecular/biological | ||||
| 2. Atypia | ||||
| Clonal TCR gene rearrangement | Present | |||
| Immunopathologic | ||||
| 1. CD2, CD3, CD5 in <59% of T cells | Any 1 | |||
| 2. CD7 in <10% of T cells | ||||
| 3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells | ||||
Common Symptoms
Symptoms of cutaneous T cell lymphoma include:[1]
References
- ↑ 1.0 1.1 Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016
- ↑ 2.0 2.1 Foss, Francine M.; Girardi, Michael (2017). "Mycosis Fungoides and Sezary Syndrome". Hematology/Oncology Clinics of North America. 31 (2): 297–315. doi:10.1016/j.hoc.2016.11.008. ISSN 0889-8588.
- ↑ 3.0 3.1 Vonderheid, Eric C.; Bernengo, Maria Grazia; Burg, Günter; Duvic, Madeleine; Heald, Peter; Laroche, Liliane; Olsen, Elise; Pittelkow, Mark; Russell-Jones, Robin; Takigawa, Masahiro; Willemze, Rein (2002). "Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas". Journal of the American Academy of Dermatology. 46 (1): 95–106. doi:10.1067/mjd.2002.118538. ISSN 0190-9622.
- ↑ Pimpinelli, Nicola; Olsen, Elise A.; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C.; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W.; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S.; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L.; Wood, Gary S. (2005). "Defining early mycosis fungoides". Journal of the American Academy of Dermatology. 53 (6): 1053–1063. doi:10.1016/j.jaad.2005.08.057. ISSN 0190-9622.