Gonadoblastoma differential diagnosis: Difference between revisions
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'''For the WikiDoc page for this topic, click [[Gonadoblastoma|here]]''' | '''For the WikiDoc page for this topic, click [[Gonadoblastoma|here]]''' | ||
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==Overview== | ==Overview== | ||
Gonadoblastoma must be differentiated from other diseases that cause virilization, and primary amenorrhea and also must be differentiated pathologically from[[dysgerminoma]], Sex-cord stromal tumors, and Sertoli-cell nodules. | Gonadoblastoma must be differentiated from other diseases that cause [[virilization,]] and [[primary amenorrhea]] and also must be differentiated pathologically from [[dysgerminoma]], [[Sex-cord]] stromal tumors, and [[Sertoli-cell]] nodules. | ||
==Differentiating Gonadoblastoma from other Diseases== | ==Differentiating Gonadoblastoma from other Diseases== | ||
Gonadoblastoma must be differentiated from other diseases that cause disorders of sex development, ambiguous genitalia, virilization, and primary amenorrhea such as: | Gonadoblastoma must be differentiated from other diseases that cause disorders of sex development, ambiguous genitalia, virilization, and primary amenorrhea such as: | ||
*17-Hydroxylase (17-OH) deficiency syndrome | *17-Hydroxylase (17-OH) deficiency syndrome | ||
*Turner Syndrome | *[[Turner syndrome|Turner Syndrome]] | ||
*Sweyer Syndrome | *Sweyer Syndrome | ||
*5-Alpha-Reductase Deficiency | *5-Alpha-Reductase Deficiency | ||
*Congenital adrenal hyperplasia | *[[Congenital adrenal hyperplasia (CAH)|Congenital adrenal hyperplasia]] | ||
*Hypospadias | *[[Hypospadias]] | ||
*Undescended testis | *Undescended testis | ||
Gonadoblastoma must be differentiated pathologically from:<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref><ref>{{cite book | last = Eble | first = John | title = Pathology and genetics of tumours of the urinary system and male genital organs | publisher = IARC Press Oxford University Press (distributor | location = Lyon Oxford | year = 2004 | isbn = 9283224159 }}</ref> | Gonadoblastoma must be differentiated pathologically from:<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref><ref>{{cite book | last = Eble | first = John | title = Pathology and genetics of tumours of the urinary system and male genital organs | publisher = IARC Press Oxford University Press (distributor | location = Lyon Oxford | year = 2004 | isbn = 9283224159 }}</ref> | ||
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|- style="background: #4479BA; color: #FFFFFF; text-align: center;" | |- style="background: #4479BA; color: #FFFFFF; text-align: center;" | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="4" |Diseases | ||
| style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="1" colspan="6" |'''Clinical manifestations''' | |||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="2" colspan="7" |Para-clinical findings | ||
| | | style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="4" colspan="1" |'''Gold standard''' | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="4" |Additional findings | ||
|- | |- | ||
| | | style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="2" colspan="3" |'''Symptoms''' | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="2" colspan="3" |Physical examination | ||
|- | |- | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" colspan="3" |Lab Findings | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" colspan="3" |Imaging | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="2" |Histopathology | ||
|- | |- | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 1 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 1 | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="1" colspan="1" |Symptom 2 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 3 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 3 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 1 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 1 | ||
! | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="1" colspan="1" |Physical exam 2 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 3 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 3 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 1 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab 1 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 2 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab 2 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 3 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab 3 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 1 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 1 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 2 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 2 | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 3 | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 3 | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 1 | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 1 | ||
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!Diseases | !Diseases | ||
!Symptom 1 | !Symptom 1 | ||
! | ! rowspan="1" colspan="1" |Symptom 2 | ||
!Symptom 3 | !Symptom 3 | ||
!Physical exam 1 | !Physical exam 1 | ||
! | ! rowspan="1" colspan="1" |Physical exam 2 | ||
!Physical exam 3 | !Physical exam 3 | ||
!Lab 1 | !Lab 1 | ||
Revision as of 18:47, 12 February 2019
For the WikiDoc page for this topic, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Gonadoblastoma must be differentiated from other diseases that cause virilization, and primary amenorrhea and also must be differentiated pathologically from dysgerminoma, Sex-cord stromal tumors, and Sertoli-cell nodules.
Differentiating Gonadoblastoma from other Diseases
Gonadoblastoma must be differentiated from other diseases that cause disorders of sex development, ambiguous genitalia, virilization, and primary amenorrhea such as:
- 17-Hydroxylase (17-OH) deficiency syndrome
- Turner Syndrome
- Sweyer Syndrome
- 5-Alpha-Reductase Deficiency
- Congenital adrenal hyperplasia
- Hypospadias
- Undescended testis
Gonadoblastoma must be differentiated pathologically from:[1][2]
- dysgerminoma
- Sex-cord stromal tumors
- Sertoli-cell nodules
Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]
On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical examination | ||||||||||||||
| Lab Findings | Imaging | Histopathology | |||||||||||||
| Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | ||||
| Differential Diagnosis 1 | |||||||||||||||
| Differential Diagnosis 2 | |||||||||||||||
| Differential Diagnosis 3 | |||||||||||||||
| Diseases | Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | Histopathology | Gold standard | Additional findings |
| Differential Diagnosis 4 | |||||||||||||||
| Differential Diagnosis 5 | |||||||||||||||
| Differential Diagnosis 6 | |||||||||||||||
References
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ Eble, John (2004). Pathology and genetics of tumours of the urinary system and male genital organs. Lyon Oxford: IARC Press Oxford University Press (distributor. ISBN 9283224159.