Gonadoblastoma natural history, complications and prognosis: Difference between revisions
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{{CMG}}; {{AE}} {{Sahar}} | {{CMG}}; {{AE}} {{Sahar}} | ||
==Overview== | ==Overview== | ||
Gonadoblastoma per se is a benign tumor, however, it has the capacity to convert to [[dysgerminoma]] or other more malignant [[Germ cell tumor|germ cell tumors]] and produce steroids with resultant [[virilization]]. Prognosis is generally excellent after removing the tumor. | Gonadoblastoma per se is a [[benign tumor]], however, it has the capacity to convert to [[dysgerminoma]] or other more [[malignant]] [[Germ cell tumor|germ cell tumors]] and produce [[steroids]] with resultant [[virilization]]. [[Prognosis]] is generally excellent after removing the [[tumor]]. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
*The gonadoblastoma usually develop in the first and second decade of life.<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> If complicated by an invasive germ cell tumor, then prognosis depends on the staging of the tumor.<ref name="978-0-323-40067-1">{{cite book | last = Saia | first = Philip | title = Clinical gynecologic oncology | publisher = Elsevier | location = Philadelphia, PA | year = 2018 | isbn = 978-0-323-40067-1 }}</ref> | *The gonadoblastoma usually develop in the first and second decade of life.<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> If complicated by an [[invasive]] [[germ cell tumor]], then [[prognosis]] depends on the [[Staging (pathology)|staging]] of the [[tumor]].<ref name="978-0-323-40067-1">{{cite book | last = Saia | first = Philip | title = Clinical gynecologic oncology | publisher = Elsevier | location = Philadelphia, PA | year = 2018 | isbn = 978-0-323-40067-1 }}</ref> | ||
*It is usually diagnosed during a workup for sex organ developmental disorders, primary amenorrhea and or virilization. | *It is usually diagnosed during a workup for [[sex organ]] developmental disorders, [[primary amenorrhea]] and or virilization. | ||
===Complications=== | ===Complications=== | ||
*Common complications of gonadoblastoma include: | *Common [[complications]] of gonadoblastoma include: | ||
**Dysgerminoma | **[[Dysgerminoma]] | ||
**Seminoma | **[[Seminoma]] | ||
**Other gonadal malignancies | **Other gonadal [[malignancies]] | ||
===Prognosis=== | ===Prognosis=== | ||
*Prognosis is generally excellent if the tumor is removed by the time of diagnosis. | *[[Prognosis]] is generally excellent if the [[tumor]] is removed by the time of [[diagnosis]]. | ||
*Depending on the presence of the coexisting germinal tumors at the time of diagnosis, the prognosis may vary. | *Depending on the presence of the coexisting germinal [[tumors]] at the time of [[diagnosis]], the [[prognosis]] may vary. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 21:11, 18 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Gonadoblastoma per se is a benign tumor, however, it has the capacity to convert to dysgerminoma or other more malignant germ cell tumors and produce steroids with resultant virilization. Prognosis is generally excellent after removing the tumor.
Natural History, Complications, and Prognosis
Natural History
- The gonadoblastoma usually develop in the first and second decade of life.[1] If complicated by an invasive germ cell tumor, then prognosis depends on the staging of the tumor.[2]
- It is usually diagnosed during a workup for sex organ developmental disorders, primary amenorrhea and or virilization.
Complications
- Common complications of gonadoblastoma include:
- Dysgerminoma
- Seminoma
- Other gonadal malignancies
Prognosis
- Prognosis is generally excellent if the tumor is removed by the time of diagnosis.
- Depending on the presence of the coexisting germinal tumors at the time of diagnosis, the prognosis may vary.
References
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ Saia, Philip (2018). Clinical gynecologic oncology. Philadelphia, PA: Elsevier. ISBN 978-0-323-40067-1.