Sandbox:Roukoz: Difference between revisions
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| style="background: #F5F5F5; padding: 5px;" |Pink or flesh-colored papule | | style="background: #F5F5F5; padding: 5px;" |Pink or flesh-colored papule | ||
| style="background: #F5F5F5; padding: 5px;" |No more additional findings | | style="background: #F5F5F5; padding: 5px;" |No more additional findings | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" |none | ||
| style="background: #F5F5F5; padding: 5px;" |Typically presents on the face | | style="background: #F5F5F5; padding: 5px;" |Typically presents on the face | ||
| style="background: #F5F5F5; padding: 5px;" |May have a "rolled" border, where the periphery is more raised than the middle. | | style="background: #F5F5F5; padding: 5px;" |May have a "rolled" border, where the periphery is more raised than the middle. | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" | | ||
| style="background: #F5F5F5; padding: 5px;" |Ulceration is frequent, and the term "rodent ulcer" refers to these ulcerated nodular BCCs | | style="background: #F5F5F5; padding: 5px;" |Ulceration is frequent, and the term "rodent ulcer" refers to these ulcerated nodular BCCs | ||
|- | |||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |'''Prurigo nodules''' | |||
| style="background: #F5F5F5; padding: 5px;" | | |||
| style="background: #F5F5F5; padding: 5px;" |Itchy | |||
| style="background: #F5F5F5; padding: 5px;" | | |||
| style="background: #F5F5F5; padding: 5px;" |Firm, dome-shaped | |||
| style="background: #F5F5F5; padding: 5px;" |ranging in size from a few millimeters to several centimeters and often symmetrically distributed | |||
| style="background: #F5F5F5; padding: 5px;" |Nodules can be flesh-colored, erythematous, or brown/black | |||
| style="background: #F5F5F5; padding: 5px;" |none | |||
| style="background: #F5F5F5; padding: 5px;" | | |||
* Extensor surfaces of the arms and legs and on the trunk | |||
* Upper back, abdomen, and sacrum | |||
| style="background: #F5F5F5; padding: 5px;" |Worsened by heat, sweating, or irritation from clothing | |||
| style="background: #F5F5F5; padding: 5px;" | | |||
* Thick, compact orthohyperkeratosis | |||
* Irregular epidermal hyperplasia or pseudoepitheliomatous hyperplasia | |||
* Focal parakeratosis with irregular acanthosis | |||
* Diminished nerve fiber density | |||
* A nonspecific dermal infiltrate containing lymphocytes, macrophages, eosinophils, and neutrophils | |||
| style="background: #F5F5F5; padding: 5px;" |Nodules range in number from few to hundreds | |||
upper midback area is usually spared | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |'''Nodular malignant melanoma''' | | style="background: #DCDCDC; padding: 5px; text-align: center;" |'''Nodular malignant melanoma''' | ||
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| style="background: #F5F5F5; padding: 5px;" |No more additional findings | | style="background: #F5F5F5; padding: 5px;" |No more additional findings | ||
| style="background: #F5F5F5; padding: 5px;" |No more additional findings | | style="background: #F5F5F5; padding: 5px;" |No more additional findings | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" |none | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" | | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" | | ||
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| style="background: #F5F5F5; padding: 5px;" |Erythema | | style="background: #F5F5F5; padding: 5px;" |Erythema | ||
| style="background: #F5F5F5; padding: 5px;" |less pigmentation, and tend to be somewhat smaller in size. | | style="background: #F5F5F5; padding: 5px;" |less pigmentation, and tend to be somewhat smaller in size. | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" | | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" | |
Revision as of 01:24, 18 February 2019
Diseases | Clinical manifestations | Para-clinical findings | Additional findings | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Skin Examination | ||||||||||
Lab Findings | Histopathology | ||||||||||
Names | Symptoms | Dermoscopic Findings | Skin exam 1 | Skin exam 2 | Skin exam 3 | Risk factors | Areas affected | Unique features | |||
Cutaneous squamous cell carcinoma |
|
Usually asymptomatic | well-demarcated, scaly patch or plaque | hyperkeratotic, or ulcerative lesions | Lesions are often erythematous but can also be skin colored or pigmented. | none | Any cutaneous surface, including the head, neck, trunk, extremities, oral mucosa, shoulders, chest and back |
|
|
SCC in situ lesions tend to grow slowly, enlarging over the course of years | |
Invasive squamous cell carcinoma | Usually asymptomatic | White circles, keratin, blood spots, and white structureless zones | Well-differentiated lesions usually appear as indurated or firm, hyperkeratotic papules, plaques, or nodules | Poorly differentiated lesions are usually fleshy, soft, granulomatous papules or nodules that lack the hyperkeratosis that is often seen in well-differentiated lesions | Poorly differentiated tumors may have ulceration, hemorrhage, or areas of necrosis. | none | same as above | same as above | same as above | same as above | |
Keratoacanthoma | keratocytic epithelial tumors | Usually asymptomatic | White circles, keratin, blood spots, and white structureless zones | Initial lesion: small pink macule
Later: papular quality and eventually forms a circumscribed nodule. |
The periphery of the nodule tends to be skin-colored or mildly erythematous and may have accompanying telangiectasias | The center of the nodule typically demonstrates a prominent keratinous core. |
|
|
a history of rapid growth within weeks favors this diagnosis |
|
|
Merkel cell carcinoma | Usually asymptomatic | Milky red areas; linear, irregular vessels; and polymorphous vessels | rapidly growing, painless, firm, nontender, shiny, flesh-colored or bluish-red, intracutaneous nodule | No more additional findings | No more additional findings | Older patients with light skin tones |
|
|
Blue-red, dome-shaped nodule | ||
Nodular basal cell carcinoma | Nodular BCC | Usually asymptomatic | Pearly papule with telangiectasias | Pink or flesh-colored papule | No more additional findings | none | Typically presents on the face | May have a "rolled" border, where the periphery is more raised than the middle. | Ulceration is frequent, and the term "rodent ulcer" refers to these ulcerated nodular BCCs | ||
Prurigo nodules | Itchy | Firm, dome-shaped | ranging in size from a few millimeters to several centimeters and often symmetrically distributed | Nodules can be flesh-colored, erythematous, or brown/black | none |
|
Worsened by heat, sweating, or irritation from clothing |
|
Nodules range in number from few to hundreds
upper midback area is usually spared | ||
Nodular malignant melanoma | Usually asymptomatic | Lump that has been rapidly growing over the past weeks | No more additional findings | No more additional findings | none | Cells proliferate downwards through the skin (vertical growth) |
| ||||
Amelanotic melanoma | Usually asymptomatic | Color usually pink, purple or normal skin color | Usually have an asymmetrical shape with an irregular border | Red, nonspecific lesion with slightly elevated borders |
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Basal cell carcinoma | Coarse scale lesion | No more additional findings | No more additional findings | ||||||||
Superficial basal cell carcinoma | Scaly patch | Erythematous lesion | No more additional findings |
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Cutaneous metastases of internal malignancy | Other sites lungs, liver, brain, skin, or bone. | No more additional findings | No more additional findings | The most frequent site of metastasis for cutaneous SCC is the regional lymph nodes; | |||||||
Benign Skin Lesions | |||||||||||
Sebaceous cell carcinoma | Yellow-nodule | Suspected due to evidence of eyelash loss | |||||||||
Rhabdomyosarcoma | Bulging of the eye or a swollen eyelid | Develops in skeletal muscles usually | |||||||||
Actinic keratoses | Pain | Hyperkeratosis | Erythema | less pigmentation, and tend to be somewhat smaller in size. | |||||||
Paget disease | Eczema-like rash of the skin | Around the genital regions of males and females. | Similar to mammary paget disease | chronic | |||||||
Inflamed seborrheic keratosis | Waxy, "stuck on," often hyperkeratotic appearance | ||||||||||
Viral warts | Verrucous lesion | Caused by HPV | |||||||||
Pyogenic granuloma | Rapidly growing | Red, dome-shaped | Friable papule with a collarette of scale | ||||||||
Bowenoid papulosis | multiple, red- to brown-colored, small papules that |
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Nummular eczema | Itchy lesions | Coin shaped spots | Chronic condition | ||||||||
Psoriasis | Flaking, inflammation | Thick, white, silvery, or red patches of skin | Chronic condition | ||||||||
Pyoderma gangrenosum | Purulent ulcer | Ragged and violaceous border | |||||||||
Venous stasis ulcers | |||||||||||
Traumatic ulcers | |||||||||||
Sebaceous Hyperplasia | Lesions can be single or multiple lesions |
Yellowish, soft, small papules on the face |
Usually on the nose, cheeks, and forehead | ||||||||
Allergic Contact Dermatitis | Itchy rash | Red rash | Not contagious | ||||||||
Atopic Dermatitis | Itchy rash | Fever | Red rash | Chronic and sometimes accompanied by asthma | |||||||
Atypical Fibroxanthoma | Erythematous, dome-shaped papule | ||||||||||
Nevus | |||||||||||
Chemical Burns | |||||||||||
Limbal Dermoid | Contains choristomatous tissue | Benign congenital tumor | |||||||||
Benign hereditary intraepithelial dyskeratosis | Rare autosomal-dominant disorder of the conjunctiva and oral mucosa | ||||||||||
primary acquired melanosis | |||||||||||
Fibrous xanthoma | Containing fibromatous elements | Arises due to disturbed systemic lipid metabolism | |||||||||
Inflamed seborrheic keratosis | Inflamed and hyperpigmented | On dermatoscopic evaluation, presence of horned cysts and hairpin-shaped blood vessels | |||||||||
Juvenile xanthogranuloma | Reddened, yellowish-tan color of lesions | Slightly raised bumps | Typically | ||||||||
Cutaneous fungal infections | |||||||||||
Desmoplastic trichoepithelioma | |||||||||||
Adnexal carcinoma | Very rare | ||||||||||
Darier disease | Keratosis follicularis | ||||||||||
Cutaneous T-cell lymphoma | Mycosis fungoides | ||||||||||
Marjolin's ulcer | Lesions in sites of chronic wounds and scars | Excessive granulation tissue, | Rolled or everted wound margins | Bleeding on touch |
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Epithelioma cuniculatum | Increased size | Verrucous carcinoma on the plantar foot | |||||||||
Anogenital | also known as giant condyloma acuminatum of Buschke-Loewenstein |
SCC in situ: Frequently, there is associated thickening of the epidermis (acanthosis), as well as hyperkeratosis and parakeratosis of the stratum corneum. In contrast to SCC in situ, actinic keratoses demonstrate only partial-thickness epidermal dysplasia.