Gonadoblastoma natural history, complications and prognosis: Difference between revisions
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
* | *Gonadoblastoma usually develops in the first and second decades of life.<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> | ||
*It is usually diagnosed during a workup for [[sex organ]] developmental disorders, [[primary amenorrhea]] and or virilization. | *If complicated by an [[invasive]] [[germ cell tumor]], then [[prognosis]] depends on the [[Staging (pathology)|staging]] of the [[tumor]].<ref name="978-0-323-40067-1">{{cite book | last = Saia | first = Philip | title = Clinical gynecologic oncology | publisher = Elsevier | location = Philadelphia, PA | year = 2018 | isbn = 978-0-323-40067-1 }}</ref> | ||
*It is usually diagnosed during a workup for [[sex organ]] developmental disorders, [[primary amenorrhea]], and/or [[virilization]]. | |||
===Complications=== | ===Complications=== | ||
*Common [[complications]] of gonadoblastoma include: | *Common [[complications]] of gonadoblastoma include: | ||
| Line 15: | Line 16: | ||
**Other gonadal [[malignancies]] | **Other gonadal [[malignancies]] | ||
===Prognosis=== | ===Prognosis=== | ||
*[[Prognosis]] is generally excellent if the [[tumor]] is removed | *[[Prognosis]] is generally excellent if the [[tumor]] is diagnosed and removed early. | ||
*Depending on the presence of the coexisting germinal [[tumors]] at the time of [[diagnosis]], the [[prognosis]] may vary. | *Depending on the presence of the coexisting germinal [[tumors]] at the time of [[diagnosis]], the [[prognosis]] may vary. | ||
==References== | ==References== | ||
Revision as of 16:12, 19 February 2019
|
Gonadoblastoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Gonadoblastoma natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Gonadoblastoma natural history, complications and prognosis |
|
FDA on Gonadoblastoma natural history, complications and prognosis |
|
CDC on Gonadoblastoma natural history, complications and prognosis |
|
Gonadoblastoma natural history, complications and prognosis in the news |
|
Blogs on Gonadoblastoma natural history, complications and prognosis |
|
Risk calculators and risk factors for Gonadoblastoma natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Gonadoblastoma per se is a benign tumor, however, it has the capacity to convert to dysgerminoma or other more malignant germ cell tumors and produce steroids with resultant virilization. Prognosis is generally excellent after removing the tumor.
Natural History, Complications, and Prognosis
Natural History
- Gonadoblastoma usually develops in the first and second decades of life.[1]
- If complicated by an invasive germ cell tumor, then prognosis depends on the staging of the tumor.[2]
- It is usually diagnosed during a workup for sex organ developmental disorders, primary amenorrhea, and/or virilization.
Complications
- Common complications of gonadoblastoma include:
- Dysgerminoma
- Seminoma
- Other gonadal malignancies
Prognosis
- Prognosis is generally excellent if the tumor is diagnosed and removed early.
- Depending on the presence of the coexisting germinal tumors at the time of diagnosis, the prognosis may vary.
References
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ Saia, Philip (2018). Clinical gynecologic oncology. Philadelphia, PA: Elsevier. ISBN 978-0-323-40067-1.