Cowden syndrome causes: Difference between revisions
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==Causes== | ==Causes== | ||
===Common Causes=== | ===Common Genetic Causes=== | ||
Common causes of [[cowden syndrome]] may include: | Common causes of [[cowden syndrome]] may include: | ||
*[[PTEN (gene)|PTEN]] [[gene]] [[mutations]] in a [[gene]] on [[chromosome 10]] | *[[PTEN (gene)|PTEN]] [[gene]] [[mutations]] in a [[gene]] on [[chromosome 10]] | ||
*[[Allele|Allelic]] [[heterogeneity]] is positive in [[cowden syndrome]] | *[[Allele|Allelic]] [[heterogeneity]] is positive in [[cowden syndrome]] | ||
===Less Common Causes=== | ===Less Common Genetic Causes=== | ||
Less common causes of [[cowden syndrome]] include: | Less common causes of [[cowden syndrome]] include:<ref name="pmid21177507">{{cite journal |vauthors=Bennett KL, Mester J, Eng C |title=Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome |journal=JAMA |volume=304 |issue=24 |pages=2724–31 |date=December 2010 |pmid=21177507 |doi=10.1001/jama.2010.1877 |url=}}</ref> | ||
*''KLLN'' (KILLIN) [[gene mutation]] | *''KLLN'' (KILLIN) [[gene mutation]] | ||
*[[Succinate dehydrogenase]] (''[[Succinate dehydrogenase|SDH]]'') [[gene mutation]] | *[[Succinate dehydrogenase]] (''[[Succinate dehydrogenase|SDH]]'') [[gene mutation]] | ||
*''SEC23B'' [[gene mutation]] | *''[[SEC23B]]'' [[gene mutation]] | ||
*''EGFR'' [[gene mutation]] | *''[[EGFR]]'' [[gene mutation]] | ||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
Revision as of 18:18, 21 February 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
The most common cause of cowden syndrome is PTEN gene mutations. PTEN hamartoma tumor syndrome (PHTS) which includes a group of many disorders Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS) and Proteus and Proteus-like syndrome (PS).
Causes
Common Genetic Causes
Common causes of cowden syndrome may include:
- PTEN gene mutations in a gene on chromosome 10
- Allelic heterogeneity is positive in cowden syndrome
Less Common Genetic Causes
Less common causes of cowden syndrome include:[1]
- KLLN (KILLIN) gene mutation
- Succinate dehydrogenase (SDH) gene mutation
- SEC23B gene mutation
- EGFR gene mutation
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Cause 1
- Cause 2
- Cause 3
- Cause 4
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- Cause 9
- Cause 10
References
- ↑ Bennett KL, Mester J, Eng C (December 2010). "Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome". JAMA. 304 (24): 2724–31. doi:10.1001/jama.2010.1877. PMID 21177507.