Desmoid tumor risk factors: Difference between revisions
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*Mostly desmoids in FAP are intra-abdominal or involve abdominal wall | *Mostly desmoids in FAP are intra-abdominal or involve abdominal wall | ||
*Most of these desmoids are unresectable associated with diffuse infiltration of mesentery | *Most of these desmoids are unresectable associated with diffuse infiltration of mesentery | ||
*FAP is associated with mutations in the ''APC'' (adenomatous polyposis coli) gene, located on chromosome 5q21-q22 | *FAP is associated with mutations in the ''APC'' (adenomatous polyposis coli) gene, located on chromosome 5q21-q22 | ||
*Sometimes, only manifestation of APC mutation is desmoid | *Sometimes, only manifestation of APC mutation is desmoid | ||
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**Pregnancy-associated high estrogen levels | **Pregnancy-associated high estrogen levels | ||
**Trauma related to the pregnancy (including a scar from a prior Cesarean section) | **Trauma related to the pregnancy (including a scar from a prior Cesarean section) | ||
* | *History of desmoid resection in prior pregnancy is associated with low recurrence risk in future pregnancies | ||
*Existing desmoid (pregnancy-associated or predating any pregnancy) managed with watchful waiting has a chance to grow during a subsequent pregnancy (but not always) | |||
*Good overall outcomes without attributable obstetric complications | |||
|- | |- | ||
|History of antecedent trauma at the tumor site (30%) | |History of antecedent trauma at the tumor site (30%) | ||
Revision as of 18:03, 27 February 2019
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Desmoid tumor Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Faizan Sheraz, M.D. [3]
Overview
Common risk factors for the development of desmoid tumor include an APC mutation 3' to codon 1399, previous abdominal surgery, and the female sex.[1]
Risk Factors
Common risk factors for the development of desmoid tumor include:[1]
| Risk factors | Associated features |
|---|---|
| Familial adenomatous polyposis (FAP) (10-20%) |
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| Gardner syndrome | |
| Specific location of APC (adenomatous polyposis coli) gene mutation i.e. 3' of codon 1444 | |
| Family history of desmoid tumor | |
| Pregnancy |
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| History of antecedent trauma at the tumor site (30%) |
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| Female gender |
- APC mutation 3' to codon 1399
Reference
- ↑ 1.0 1.1 Jenayah, Amel Achour; Bettaieb, Hajer; Saoudi, Sarra; Gharsa, Anissa; Sfar, Ezzeddine; Boudaya, Fethia; Chelli, Dalenda (2015). "Desmoid tumors: clinical features and treatment options: a case report and a review of literature". Pan African Medical Journal. 21. doi:10.11604/pamj.2015.21.93.7037. ISSN 1937-8688.