Desmoid tumor risk factors: Difference between revisions

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!Associated features
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|Familial adenomatous polyposis (FAP) (10-20%)
|Familial adenomatous polyposis (FAP) (10-20%)<ref name="pmid20830713">{{cite journal| author=Nieuwenhuis MH, Casparie M, Mathus-Vliegen LM, Dekkers OM, Hogendoorn PC, Vasen HF| title=A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. | journal=Int J Cancer | year= 2011 | volume= 129 | issue= 1 | pages= 256-61 | pmid=20830713 | doi=10.1002/ijc.25664 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20830713  }} </ref><ref name="pmid16736290">{{cite journal| author=Fallen T, Wilson M, Morlan B, Lindor NM| title=Desmoid tumors -- a characterization of patients seen at Mayo Clinic 1976-1999. | journal=Fam Cancer | year= 2006 | volume= 5 | issue= 2 | pages= 191-4 | pmid=16736290 | doi=10.1007/s10689-005-5959-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16736290  }} </ref><ref name="pmid26663236">{{cite journal| author=Koskenvuo L, Peltomäki P, Renkonen-Sinisalo L, Gylling A, Nieminen TT, Ristimäki A et al.| title=Desmoid tumor patients carry an elevated risk of familial adenomatous polyposis. | journal=J Surg Oncol | year= 2016 | volume= 113 | issue= 2 | pages= 209-12 | pmid=26663236 | doi=10.1002/jso.24117 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26663236  }} </ref>
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*852 times elevated risk of developing desmoids in FAP patients as compared to general population
*852 times elevated risk of developing desmoids in FAP patients as compared to general population

Revision as of 18:07, 27 February 2019

Desmoid tumor Microchapters

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Risk Factors

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Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Common risk factors for the development of desmoid tumor include an APC mutation 3' to codon 1399, previous abdominal surgery, and the female sex.[1]

Risk Factors

Common risk factors for the development of desmoid tumor include:[1]

Common risk factors for development of desmoid tumor
Risk factors Associated features
Familial adenomatous polyposis (FAP) (10-20%)[2][3][4]
  • 852 times elevated risk of developing desmoids in FAP patients as compared to general population
  • Mostly desmoids in FAP are intra-abdominal or involve abdominal wall
  • Most of these desmoids are unresectable associated with diffuse infiltration of mesentery
  • FAP is associated with mutations in the APC (adenomatous polyposis coli) gene, located on chromosome 5q21-q22
  • Sometimes, only manifestation of APC mutation is desmoid
  • FAP screening recommended in patients with multiple intraabdominal or truncal desmoid tumors
  • Risk of finding FAP in patients who develop a desmoid without a prior history of FAP is relatively low (4.8% only)
Gardner syndrome
Specific location of APC (adenomatous polyposis coli) gene mutation i.e. 3' of codon 1444
Family history of desmoid tumor
Pregnancy
  • Extraabdominal and abdominal desmoids occur in women during or following pregnancy
  • Presents as an abdominal mass separate from uterus
  • Occurs in pregnancy due to:
    • Pregnancy-associated high estrogen levels
    • Trauma related to the pregnancy (including a scar from a prior Cesarean section)
  • History of desmoid resection in prior pregnancy is associated with low recurrence risk in future pregnancies
  • Existing desmoid (pregnancy-associated or predating any pregnancy) managed with watchful waiting has a chance to grow during a subsequent pregnancy (but not always)
  • Good overall outcomes without attributable obstetric complications
History of antecedent trauma at the tumor site (30%)
  • Previous abdominal surgery in patients with FAP
  • In one-half patients, desmoids can develop within first five years post-surgery
Female gender
  • APC mutation 3' to codon 1399

Reference

  1. ↑ 1.0 1.1 Jenayah, Amel Achour; Bettaieb, Hajer; Saoudi, Sarra; Gharsa, Anissa; Sfar, Ezzeddine; Boudaya, Fethia; Chelli, Dalenda (2015). "Desmoid tumors: clinical features and treatment options: a case report and a review of literature". Pan African Medical Journal. 21. doi:10.11604/pamj.2015.21.93.7037. ISSN 1937-8688.
  2. ↑ Nieuwenhuis MH, Casparie M, Mathus-Vliegen LM, Dekkers OM, Hogendoorn PC, Vasen HF (2011). "A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses". Int J Cancer. 129 (1): 256–61. doi:10.1002/ijc.25664. PMID 20830713.
  3. ↑ Fallen T, Wilson M, Morlan B, Lindor NM (2006). "Desmoid tumors -- a characterization of patients seen at Mayo Clinic 1976-1999". Fam Cancer. 5 (2): 191–4. doi:10.1007/s10689-005-5959-5. PMID 16736290.
  4. ↑ Koskenvuo L, Peltomäki P, Renkonen-Sinisalo L, Gylling A, Nieminen TT, Ristimäki A; et al. (2016). "Desmoid tumor patients carry an elevated risk of familial adenomatous polyposis". J Surg Oncol. 113 (2): 209–12. doi:10.1002/jso.24117. PMID 26663236.

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