Desmoid tumor other diagnostic studies: Difference between revisions

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(aids histologic diagnosis)
(aids histologic diagnosis)
|Spindle cells on immunohistochemical stains show the following features:
|Spindle cells on immunohistochemical stains show the following features:
* Positive for: vimentin and smooth muscle actin and nuclear beta-catenin but are generally negative for desmin, cytokeratins, and S-100
*Positive for:
 
**Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity)
*Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)
**Vimentin
**Smooth muscle actin
*Negative for:
**Desmin
**Cytokeratins
**S-100
|-
|-
|Antibodies
|Antibodies

Revision as of 19:59, 1 March 2019

Desmoid tumor Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Desmoid tumor from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

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Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

Antibodies including smooth muscle actin, desmin and KIT are often examined to aid in distinguishing desmoids from other tumors.

Other diagnostic studies

Characteristic features of desmoid tumors on immunohistochemistry and relevant antibodies
Other diagnostic tests Associated characteristics features
Immunohistochemistry

(aids histologic diagnosis)

Spindle cells on immunohistochemical stains show the following features:
  • Positive for:
    • Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity)
    • Vimentin
    • Smooth muscle actin
  • Negative for:
    • Desmin
    • Cytokeratins
    • S-100
Antibodies In order to distinguish desmoid tumors from other tumors, following antibodies are often examined:
  • Smooth muscle actin
  • Desmin
  • KIT

Reference

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