Desmoid tumor other diagnostic studies: Difference between revisions

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==Overview==
==Overview==
Antibodies including smooth muscle actin, desmin and KIT are often examined to aid in distinguishing desmoids from other tumors.
Immunohistochemical staining of spindle cells of desmoid tumors are positive for nuclear beta-catenin, vimentin, alpha smooth muscle actin, muscle actin and negative for desmin, cytokeratins, and S-100. Antibodies like smooth muscle actin, desmin and KIT may be helpful in distinguishing desmoid tumors from other tumors. In addition, APC germline mutations may be performed in patients with sporadic desmoid tumors with no clinical or famililal signs of FAP but having a family history of colorectal carcinoma in at least one family member.


==Other diagnostic studies==
==Other diagnostic studies==
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**Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity)
**Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity)
**Vimentin
**Vimentin
**Smooth muscle actin
**Alpha smooth muscle actin
**Muscle actin
*Negative for:
*Negative for:
**Desmin
**Desmin
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*Desmin
*Desmin
*KIT
*KIT
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|'''APC germline mutational analysis'''
|
* Sporadic desmoid tumor patients with no clinical or familial signs of familial adenomatous polyposis (FAP) but having a family history of colorectal carcinoma in at least one family member
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|}



Revision as of 16:01, 5 March 2019

Desmoid tumor Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Desmoid tumor from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

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Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

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Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

Immunohistochemical staining of spindle cells of desmoid tumors are positive for nuclear beta-catenin, vimentin, alpha smooth muscle actin, muscle actin and negative for desmin, cytokeratins, and S-100. Antibodies like smooth muscle actin, desmin and KIT may be helpful in distinguishing desmoid tumors from other tumors. In addition, APC germline mutations may be performed in patients with sporadic desmoid tumors with no clinical or famililal signs of FAP but having a family history of colorectal carcinoma in at least one family member.

Other diagnostic studies

Characteristic features of desmoid tumors on immunohistochemistry and relevant antibodies
Other diagnostic tests Associated characteristics features
Immunohistochemistry

(aids histologic diagnosis)

Spindle cells on immunohistochemical stains show the following features:
  • Positive for:
    • Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity)
    • Vimentin
    • Alpha smooth muscle actin
    • Muscle actin
  • Negative for:
    • Desmin
    • Cytokeratins
    • S-100
Antibodies In order to distinguish desmoid tumors from other tumors, following antibodies are often examined:
  • Smooth muscle actin
  • Desmin
  • KIT
APC germline mutational analysis
  • Sporadic desmoid tumor patients with no clinical or familial signs of familial adenomatous polyposis (FAP) but having a family history of colorectal carcinoma in at least one family member

Reference

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