Desmoid tumor other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Antibodies | Immunohistochemical staining of spindle cells of desmoid tumors are positive for nuclear beta-catenin, vimentin, alpha smooth muscle actin, muscle actin and negative for desmin, cytokeratins, and S-100. Antibodies like smooth muscle actin, desmin and KIT may be helpful in distinguishing desmoid tumors from other tumors. In addition, APC germline mutations may be performed in patients with sporadic desmoid tumors with no clinical or famililal signs of FAP but having a family history of colorectal carcinoma in at least one family member. | ||
==Other diagnostic studies== | ==Other diagnostic studies== | ||
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**Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity) | **Nuclear beta-catenin (regardless of the site, 90% of desmoids show nuclear reactivity, relatively high specificity) | ||
**Vimentin | **Vimentin | ||
** | **Alpha smooth muscle actin | ||
**Muscle actin | |||
*Negative for: | *Negative for: | ||
**Desmin | **Desmin | ||
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*Desmin | *Desmin | ||
*KIT | *KIT | ||
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|'''APC germline mutational analysis''' | |||
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* Sporadic desmoid tumor patients with no clinical or familial signs of familial adenomatous polyposis (FAP) but having a family history of colorectal carcinoma in at least one family member | |||
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Revision as of 16:01, 5 March 2019
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Desmoid tumor Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Immunohistochemical staining of spindle cells of desmoid tumors are positive for nuclear beta-catenin, vimentin, alpha smooth muscle actin, muscle actin and negative for desmin, cytokeratins, and S-100. Antibodies like smooth muscle actin, desmin and KIT may be helpful in distinguishing desmoid tumors from other tumors. In addition, APC germline mutations may be performed in patients with sporadic desmoid tumors with no clinical or famililal signs of FAP but having a family history of colorectal carcinoma in at least one family member.
Other diagnostic studies
| Other diagnostic tests | Associated characteristics features |
|---|---|
| Immunohistochemistry
(aids histologic diagnosis) |
Spindle cells on immunohistochemical stains show the following features:
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| Antibodies | In order to distinguish desmoid tumors from other tumors, following antibodies are often examined:
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| APC germline mutational analysis |
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