Thrombotic thrombocytopenic purpura differential diagnosis: Difference between revisions
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**[[Evans syndrome]] disseminated [[intravascular]] [[coagulation]] [[pregnancy]]-associated such as: | **[[Evans syndrome]] disseminated [[intravascular]] [[coagulation]] [[pregnancy]]-associated such as: | ||
***[[HELLP syndrome|HELLP]] ([[Hemolysis|haemolysis]] | ***[[HELLP syndrome|HELLP]] ([[Hemolysis|haemolysis]] | ||
*** | ***Elevated [[liver]] [[enzymes]] and low [[platelets]]) | ||
***[[eclampsia]] | ***[[eclampsia]] | ||
** | **[[Hemolytic-uremic syndrome|Haemolytic uraemic syndrome]] | ||
**Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors | **[[Drugs]]: [[quinine]], [[simvastatin]], [[interferon]], [[Calcineurin]] [[Inhibitor|inhibitors]] | ||
**Malignant hypertension | **Malignant hypertension | ||
**Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus) | **Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus) | ||
Revision as of 14:52, 6 March 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
The main differential diagnosis of TTP is hemolytic-uremic syndrome. TTP should be diffrential from the other desaeses such as TMA syndromes, disseminated intravascular coagulation ,hypertension, immune thrombocytopenic purpura (ITP)
- Malignant hypertension
- Hematological abnormalities
- Ischemic manifestations linked to autoimmune diseases
Differential Diagnosis
The main differential diagnosis of TTP is hemolytic-uremic syndrome (HUS, which has neurosymptoms, renal failure, hypertension and fever). Note that ADAMTS13 activity is normal in HUS.[1]
TTP must be differentiated from
- TMA syndromes
- Disseminated intravascular coagulation
- Hypertension
- Immune hrombocytopenic purpura (ITP)
- Malignant hypertension
- Hematological abnormalities
- Ischemic manifestations linked to autoimmune diseases
Differentiating TTP from other diseases on the basis of Symptoms:
- On the basis rombocytopenia, MAHA, fluctuating neurological signs, renal faluer and fever, TTP must be differentiated from[2]
- Autoimmune haemolysis
- Evans syndrome disseminated intravascular coagulation pregnancy-associated such as:
- Haemolytic uraemic syndrome
- Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors
- Malignant hypertension
- Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus)
- Severe bacterial (meningococcus, pneumococcus)
- Fungal Autoimmune disease (lupus nephritis, acute scleroderma)
- Vasculitis Haemolytic uraemic syndrome (diarrhoea positive/negative)
- Malignancy Catastrophic antiphospholipid syndro
References
- ↑ Joly, Bérangère S.; Coppo, Paul; Veyradier, Agnès (2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–2846. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971.
- ↑ Karpman, Diana; Loos, Sebastian; Tati, Ramesh; Arvidsson, Ida (2017). "Haemolytic uraemic syndrome". Journal of Internal Medicine. 281 (2): 123–148. doi:10.1111/joim.12546. ISSN 0954-6820.