Thrombotic thrombocytopenic purpura differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
| Line 35: | Line 35: | ||
***[[simvastatin]] | ***[[simvastatin]] | ||
***[[interferon]] | ***[[interferon]] | ||
***[[Calcineurin]] | ***[[Calcineurin]] [[Inhibitor|inhibitors]] | ||
**[[Malignant]] [[hypertension]] | |||
**Malignant hypertension | **[[Infection|Infections]] (typically [[viral]] ([[cytomegalovirus]], [[adenovirus]], [[herpes simplex]] [[Virus (biology)|virus]]) | ||
**Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus) | **Severe [[bacterial]] ([[meningococcus]], [[pneumococcus]]) | ||
**Severe bacterial (meningococcus, pneumococcus) | **[[Fungal]] [[autoimmune]] [[disease]] ([[lupus nephritis]], [[Acute (medicine)|acute]] [[scleroderma]]) | ||
**Fungal | **[[Vasculitis]] [[Hemolytic-uremic syndrome|haemolytic uraemic syndrome]] ([[Diarrhea|diarrhoea]] positive/negative) | ||
**Vasculitis | **[[Malignancy]] [[catastrophic antiphospholipid syndrome]] | ||
**Malignancy | |||
{| | {| | ||
Revision as of 15:00, 6 March 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
The main differential diagnosis of TTP is hemolytic-uremic syndrome. TTP should be diffrential from the other desaeses such as TMA syndromes, disseminated intravascular coagulation ,hypertension, immune thrombocytopenic purpura (ITP)
- Malignant hypertension
- Hematological abnormalities
- Ischemic manifestations linked to autoimmune diseases
Differential Diagnosis
The main differential diagnosis of TTP is hemolytic-uremic syndrome (HUS, which has neurosymptoms, renal failure, hypertension and fever). Note that ADAMTS13 activity is normal in HUS.[1]
TTP must be differentiated from
- TMA syndromes
- Disseminated intravascular coagulation
- Hypertension
- Immune hrombocytopenic purpura (ITP)
- Malignant hypertension
- Hematological abnormalities
- Ischemic manifestations linked to autoimmune diseases
Differentiating TTP from other diseases on the basis of Symptoms:
- On the basis rombocytopenia, MAHA, fluctuating neurological signs, renal faluer and fever, TTP must be differentiated from[2]
- Autoimmune haemolysis
- Evans syndrome disseminated intravascular coagulation pregnancy-associated such as:
- Haemolytic uraemic syndrome
- Drugs:
- Malignant hypertension
- Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus)
- Severe bacterial (meningococcus, pneumococcus)
- Fungal autoimmune disease (lupus nephritis, acute scleroderma)
- Vasculitis haemolytic uraemic syndrome (diarrhoea positive/negative)
- Malignancy catastrophic antiphospholipid syndrome
References
- ↑ Joly, Bérangère S.; Coppo, Paul; Veyradier, Agnès (2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–2846. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971.
- ↑ Karpman, Diana; Loos, Sebastian; Tati, Ramesh; Arvidsson, Ida (2017). "Haemolytic uraemic syndrome". Journal of Internal Medicine. 281 (2): 123–148. doi:10.1111/joim.12546. ISSN 0954-6820.