Adenocarcinoma: Difference between revisions
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==Overview== | |||
'''Adenocarcinoma''' is a form of [[carcinoma]] that originates in [[glandular]] tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a [[gland]], as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans.<ref>Fauquier, D.A., Gulland, F.M.D.,(Marine Mammal Center), Haulena, M., Spraker, T., ‘’Biliary adenocarcinoma in a stranded Northern elephant seal (‘’Mirounga angustirortsis’‘)’‘, Journal of Wildlife Diseases 39(3):723-726 (2003)</ref> The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and '[[carcinoma]]', which describes a cancer that has developed in the [[epithelial]] cells. It can first present as an [[adenoma]] (a glandular tumor that is [[benign]]). | |||
==Pathophysiology== | |||
Examples of tissues where adenocarcinomas may arise: | |||
* [[Breast cancer]] | |||
* [[Colon cancer]] | |||
* [[Lung cancer]] | |||
* [[Prostate cancer]] | |||
* [[Stomach cancer]] | |||
* [[Pancreatic cancer]] (99% of pancreatic cancers are ductal adenocarcinomas [http://www.emedicine.com/radio/topic516.htm]) | |||
* [[Cervical cancer]] | |||
* [[Vaginal cancer]] | |||
===Gross Pathology=== | |||
<gallery> | |||
Image:gastcarc_enface.jpg|This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a "very suspicious" ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is a seen face view of the ulcer. The pyloric margin is to the left. The ulcer is on the lesser curvature. | |||
Image:Gastcarc xsec.jpg|This is a longitudinal section cut in the plane of the lesser curvature. The pylorus is to the left. Note several prominent nodes of the lesser omentum; these contained metastatic cancer. | |||
</gallery> | |||
==Physical Examination== | |||
===Adenocarcinoma-In The Submandibular Salivary Glands=== | |||
<gallery widths="200px"> | |||
180.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>] | |||
181.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>] | |||
182.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>] | |||
</gallery> | |||
==Differential Diagnosis== | |||
{| class="wikitable" | {| class="wikitable" | ||
| | |- style="background: #4479BA; color: #FFFFFF; text-align: center;" | ||
! | ! rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Diseases | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Risk factors/Epidemiology | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | History | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Clinical Findings | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Gross Pathology | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Histopathology | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Immunohistochemistry | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Lab Findings | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Imaging | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Metastatic Potential | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Gold Standard | ||
! | ! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Additional Findings | ||
|- | |- | ||
! | ! | ||
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==References== | ==References== | ||
Revision as of 14:04, 7 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Adenocarcinoma is a form of carcinoma that originates in glandular tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans.[1] The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and 'carcinoma', which describes a cancer that has developed in the epithelial cells. It can first present as an adenoma (a glandular tumor that is benign).
Pathophysiology
Examples of tissues where adenocarcinomas may arise:
- Breast cancer
- Colon cancer
- Lung cancer
- Prostate cancer
- Stomach cancer
- Pancreatic cancer (99% of pancreatic cancers are ductal adenocarcinomas [2])
- Cervical cancer
- Vaginal cancer
Gross Pathology
-
This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a "very suspicious" ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is a seen face view of the ulcer. The pyloric margin is to the left. The ulcer is on the lesser curvature.
-
This is a longitudinal section cut in the plane of the lesser curvature. The pylorus is to the left. Note several prominent nodes of the lesser omentum; these contained metastatic cancer.
Physical Examination
Adenocarcinoma-In The Submandibular Salivary Glands
-
Adenocarcinoma-In The Submandibular Salivary Glands
Adapted from Dermatology Atlas -
Adenocarcinoma-In The Submandibular Salivary Glands
Adapted from Dermatology Atlas -
Adenocarcinoma-In The Submandibular Salivary Glands
Adapted from Dermatology Atlas
Differential Diagnosis
| Diseases | Risk factors/Epidemiology | History | Clinical Findings | Gross Pathology | Histopathology | Immunohistochemistry | Lab Findings | Imaging | Metastatic Potential | Gold Standard | Additional Findings |
|---|---|---|---|---|---|---|---|---|---|---|---|
References
- ↑ Fauquier, D.A., Gulland, F.M.D.,(Marine Mammal Center), Haulena, M., Spraker, T., ‘’Biliary adenocarcinoma in a stranded Northern elephant seal (‘’Mirounga angustirortsis’‘)’‘, Journal of Wildlife Diseases 39(3):723-726 (2003)