Meningioma pathophysiology: Difference between revisions

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==Pathogenesis==
==Pathogenesis==
*Meningiomas are the most common benign tumors of the brain. They are also the most common nonglial brain tumors.<ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>
*Meningiomas are the most common benign tumors of the brain. They are also the most common nonglial brain tumors.<ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>
*Meningioma arises from the [[arachnoid]] "cap" cells, which are normally involved in the protection of the [[central nervous system]] by forming a thick envelope of meninges around the [[brain]] and [[spinal cord]].<ref name="pmid20821343">Wiemels J, Wrensch M, Claus EB (2010) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20821343 Epidemiology and etiology of meningioma.] ''J Neurooncol'' 99 (3):307-14. [http://dx.doi.org/10.1007/s11060-010-0386-3 DOI:10.1007/s11060-010-0386-3] PMID: [https://pubmed.gov/20821343 20821343]</ref>
*Meningioma arises from the [[arachnoid]] "cap" cells, which are normally involved in the protection of the [[central nervous system]] by forming a thick envelope of meninges around the [[brain]] and [[spinal cord]]. Arachnoid cap cells are commonly found in the base of the skill and perivenous sinuses.<ref name="pmid20821343">Wiemels J, Wrensch M, Claus EB (2010) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20821343 Epidemiology and etiology of meningioma.] ''J Neurooncol'' 99 (3):307-14. [http://dx.doi.org/10.1007/s11060-010-0386-3 DOI:10.1007/s11060-010-0386-3] PMID: [https://pubmed.gov/20821343 20821343]</ref><ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>
*The majority of meningiomas are [[benign]](90%), about 6% are atypical, and 2% are malignant.<ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>
*The majority of meningiomas are [[benign]](90%), about 6% are atypical, and 2% are malignant.<ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>
*Some meningiomas may be positive for progesterone receptors on histological examination. This can lead to increased tumor size and symptom burden during pregnancy and the luteal phase of the menstural cycle.<ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>
*Some meningiomas may be positive for progesterone receptors on histological examination. This can lead to increased tumor size and symptom burden during pregnancy and the luteal phase of the menstural cycle.<ref name="pmid29492130">{{cite journal| author=Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF et al.| title=Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy. | journal=Asian J Neurosurg | year= 2018 | volume= 13 | issue= 1 | pages= 86-89 | pmid=29492130 | doi=10.4103/1793-5482.181115 | pmc=5820904 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29492130  }} </ref>

Revision as of 21:20, 18 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Meningioma arises from the arachnoid "cap" cells, which are normally involved in the protection of the central nervous system by forming a thick envelope of meninges around the brain and spinal cord.[1][2][3] The majority of meningiomas are benign. Development of meningioma is the result of multiple genetic mutations The majority of meningioma cases involve a deletion of the neurofibromatosis 2 gene located on chromosome 22. On gross pathology, a gray, well-circumscribed, dome-shaped mass is a characteristic finding of meningioma. On microscopic histopathological analysis, whorled appearance, calcification, and psammoma bodies are characteristic findings of meningioma.[4]

Pathogenesis

  • Meningiomas are the most common benign tumors of the brain. They are also the most common nonglial brain tumors.[5]
  • Meningioma arises from the arachnoid "cap" cells, which are normally involved in the protection of the central nervous system by forming a thick envelope of meninges around the brain and spinal cord. Arachnoid cap cells are commonly found in the base of the skill and perivenous sinuses.[6][5]
  • The majority of meningiomas are benign(90%), about 6% are atypical, and 2% are malignant.[5]
  • Some meningiomas may be positive for progesterone receptors on histological examination. This can lead to increased tumor size and symptom burden during pregnancy and the luteal phase of the menstural cycle.[5]
  • The exact pathophysiology of meningioma depends on the histological subtype of the tumor.
  • Meningioma may be located either intradural or extradural along the central nervous system.[7]
  • Meningiomas are frequently found attached to the dura surrounding the brain tissue in several locations that include:[1]

Genetics

  • Development of meningioma is the result of multiple genetic mutations.[1]
  • The majority of meningioma cases involve a deletion of the neurofibromatosis 2 gene located on chromosome 22.
  • Other genes involved in the pathogenesis of meningioma include:

Gross Pathology

  • On gross pathology, a gray, well-circumscribed, dome-shaped mass is a characteristic finding of meningioma.[1]


Gross pathology: Cut surface of a resected meningioma[8]

Microscopic Pathology

  • On microscopic histopathological analysis, whorled appearance, calcification, and psammoma bodies are characteristic findings of meningioma.[4]
  • The table below differentiates between the three main groups of meningioma according to WHO histological classification:[2][3][4]
Grade Histologic features Image

Benign (Grade I) meningioma

Less then 4 mitosis/10 HPF, no atypia

Grade 1 Meningioma

Atypical (Grade II) meningioma

Brain invasion, 4 or more mitosis/10 HPF, necrosis, increased cell count, high nucleus:cytoplasm ratio, increased nucleoli size, presence of sheeting

Grade 2 menigioma

Anaplastic (Grade III) meningioma

20 or more mitoses/10 HPF, histology may be similar to carcinoma or sarcoma

Grade 3 menigioma


  • Shown below is a series of microscopic images of different subtypes of meningioma:[4]
  • Meningothelial meningioma with syncytial appearance and whorl formation

    Meningothelial meningioma with syncytial appearance and whorl formation

  • Meningothelial meningioma with psammoma body

    Meningothelial meningioma with psammoma body

  • Meningothelial meningioma with onion bulb formation

    Meningothelial meningioma with onion bulb formation

  • Meningothelial meningioma on HPS stain

    Meningothelial meningioma on HPS stain

  • Fibrous meningioma with spindle cells in parallel bundles

    Fibrous meningioma with spindle cells in parallel bundles

  • Fibrous meingioma on EMA stain

    Fibrous meingioma on EMA stain

  • Transitional meningioma with coexisting lobular and fasicular growth patterns

    Transitional meningioma with coexisting lobular and fasicular growth patterns

  • Psammomatous meningioma with numerous psammoma bodies

    Psammomatous meningioma with numerous psammoma bodies

  • Angiomatous meningioma with hyalinized vessels

    Angiomatous meningioma with hyalinized vessels

  • Microcystic meningioma with cystic appearance and increased pleomorphism of the elongated cells

    Microcystic meningioma with cystic appearance and increased pleomorphism of the elongated cells

  • Secretory meningioma with secretory granules

    Secretory meningioma with secretory granules

  • Secretory meningioma with PAS stain positive secretory granules

    Secretory meningioma with PAS stain positive secretory granules

  • Chordoid meningioma with myxoid appearance

    Chordoid meningioma with myxoid appearance

  • Papillary meningioma with discohesive tumor cells located around a fibrovascular core and perivascular pseudo- rosettes

    Papillary meningioma with discohesive tumor cells located around a fibrovascular core and perivascular pseudo- rosettes

  • Rhabdoid meningioma with abundant cytoplasm and cross-striations

    Rhabdoid meningioma with abundant cytoplasm and cross-striations

References

  1. ↑ 1.0 1.1 1.2 1.3 Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_note-pmid7731706-9 Accessed on September, 25 2015
  2. ↑ 2.0 2.1 Meningioma. Canadian Cancer Society http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/meningioma/?region=mb September, 25 2015
  3. ↑ 3.0 3.1 3.2 Meningeoma. Radiopaedia(2015)http://radiopaedia.org/articles/meningioma Accessed on September, 25 2015
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Meningioma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Meningioma#Quick_overview accessed on September, 25 2015
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gurcay AG, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu OF; et al. (2018). "Diagnosis, Treatment, and Management Strategy of Meningioma during Pregnancy". Asian J Neurosurg. 13 (1): 86–89. doi:10.4103/1793-5482.181115. PMC 5820904. PMID 29492130.
  6. ↑ Wiemels J, Wrensch M, Claus EB (2010) Epidemiology and etiology of meningioma. J Neurooncol 99 (3):307-14. DOI:10.1007/s11060-010-0386-3 PMID: 20821343
  7. ↑ Meningioma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Meningioma#Quick_overview Accessed on September, 25 2015
  8. ↑ Image courtesy of Dr Dharam Ramnani Radiopaedia(original file "here"). Creative Commons BY-SA-NC


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