Mast cell tumor physical examination: Difference between revisions
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*[[Tachycardia]] | *[[Tachycardia]] | ||
===Skin=== | ===Skin=== | ||
*'''Urticaria pigmentosa''': | *'''Urticaria pigmentosa''':<ref name="pmid14018418">{{cite journal |vauthors=CAPLAN RM |title=The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases |journal=Arch Dermatol |volume=87 |issue= |pages=146–57 |date=February 1963 |pmid=14018418 |doi= |url=}}</ref> | ||
:*Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | :*Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | ||
:*Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. | :*Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2], Suveenkrishna Pothuru, M.B,B.S. [3]
Overview
Physical examination for mast cell tumor include inspection for a large assortment of types of skin lesions, testing for dermatographism (Darier's sign), and palpating for hepatosplenomegaly and lymphadenopathy.[1]
Physical Examination
Vital signs
Skin
- Urticaria pigmentosa:[2]
- Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.[3]
- Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas.
- The trunk and thigh are more commonly involved with sparing of face, palms and soles.
- Darier’s sign:[4]
- Lesions urticate in response to physical irritation.
- Localized erythema and urticaria erupts within short period of time (minutes) in response to physical irritation.
- Diffuse Cutaneous Mastocytosis
- Diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness.[3]
Abdomen
References
- ↑ Molderings, Gerhard J; Brettner, Stefan; Homann, Jürgen; Afrin, Lawrence B (2011). "Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options". Journal of Hematology & Oncology. 4 (1): 10. doi:10.1186/1756-8722-4-10. ISSN 1756-8722.
- ↑ CAPLAN RM (February 1963). "The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases". Arch Dermatol. 87: 146–57. PMID 14018418.
- ↑ 3.0 3.1 Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
- ↑ Soter NA (June 2000). "Mastocytosis and the skin". Hematol. Oncol. Clin. North Am. 14 (3): 537–55, vi. PMID 10909039.