Neurofibroma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]

Overview

Neurofibroma may be classified into 6 subtypes: localised neurofibroma, diffuse neurofibroma, cutaneous/dermal neurofibroma, plexiform neurofibroma, intramuscular and intraneural neurofibroma.

Classification

Neurofibroma may be classified into following 5 subtypes:

Types of neurofibromas	Characteristics/Description
Cutaneous/Dermal/Localized (90%)	Most common These are skin tumors
Sub-cutaneous	Common Present underneath the skin Can be single tumors or chains They are often a form of plexiform neurofibromas
Diffuse	Uncommon Squishy Run through the full skin thickness Edges are difficult to define
Intramuscular	Common Usually isolated tumors in the muscle Sometimes, they can occur in chains and are plexiform neurofibromas
Plexiform	Usually present on large nerves Have more connective tissue that separates the nerve fibers Generally believed to be present at birth

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