Ovarian germ cell tumor medical therapy: Difference between revisions
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{{CMG}}{{AE}} {{Sahar}} | {{CMG}}{{AE}} {{Sahar}} | ||
==Overview== | ==Overview== | ||
Among [[ovarian]] [[germ cell]] [[tumors]], only [[dysgerminoma]] is [[ | Among [[ovarian]] [[germ cell]] [[tumors]], only [[dysgerminoma]] is radiosensitive. | ||
[[Radiotherapy]] is not anymore the first option of treatment for [[dysgerminoma]] considering its association with [[ovarian failure]] development. | |||
==Radiotherapy== | ==Radiotherapy== | ||
* Not all the [[ovarian]] [[germ cell]] [[tumors]] are | * Not all the [[ovarian]] [[germ cell]] [[tumors]] are radiosensitive.<ref name="pmid12733128">{{cite journal |vauthors=Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN |title=Pathology and classification of ovarian tumors |journal=Cancer |volume=97 |issue=10 Suppl |pages=2631–42 |date=May 2003 |pmid=12733128 |doi=10.1002/cncr.11345 |url=}}</ref> | ||
* [[Dysgerminoma]] is a | * [[Dysgerminoma]] is a radiosensitive [[tumor]]. | ||
* [[Radiotherapy]] is not the first option for treating [[dysgerminoma]] and it reserved for patients for whom [[chemotherapy]] is contraindicated for whatever reason. | * [[Radiotherapy]] is not the first option for treating [[dysgerminoma]] and it reserved for patients for whom [[chemotherapy]] is contraindicated for whatever reason. | ||
* Whole | * Whole [[abdominal]] [[radiotherapy]] is used for the treatment of [[dysgerminoma]], however, it may be associated with [[ovarian failure]].<ref name="MitchellGershenson1991">{{cite journal|last1=Mitchell|first1=Michele Follen|last2=Gershenson|first2=David M.|last3=Soeters|first3=Robbert-Paul|last4=Eifel|first4=Patricia J.|last5=Delclos|first5=Luis|last6=Wharton|first6=J. Taylor|title=Long-term effects of radiation therapy on patients with ovarian dysgerminoma|journal=Cancer|volume=67|issue=4|year=1991|pages=1084–1090|issn=0008-543X|doi=10.1002/1097-0142(19910215)67:4<1084::AID-CNCR2820670436>3.0.CO;2-E}}</ref> | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Among ovarian germ cell tumors, only dysgerminoma is radiosensitive. Radiotherapy is not anymore the first option of treatment for dysgerminoma considering its association with ovarian failure development.
Radiotherapy
- Not all the ovarian germ cell tumors are radiosensitive.[1]
- Dysgerminoma is a radiosensitive tumor.
- Radiotherapy is not the first option for treating dysgerminoma and it reserved for patients for whom chemotherapy is contraindicated for whatever reason.
- Whole abdominal radiotherapy is used for the treatment of dysgerminoma, however, it may be associated with ovarian failure.[2]
References
- ↑ Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN (May 2003). "Pathology and classification of ovarian tumors". Cancer. 97 (10 Suppl): 2631–42. doi:10.1002/cncr.11345. PMID 12733128.
- ↑ Mitchell, Michele Follen; Gershenson, David M.; Soeters, Robbert-Paul; Eifel, Patricia J.; Delclos, Luis; Wharton, J. Taylor (1991). "Long-term effects of radiation therapy on patients with ovarian dysgerminoma". Cancer. 67 (4): 1084–1090. doi:10.1002/1097-0142(19910215)67:4<1084::AID-CNCR2820670436>3.0.CO;2-E. ISSN 0008-543X.