Proteus syndrome: Difference between revisions
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* Proteus syndrome is one of the syndromes which falls under PTEN hamartoma tumor syndromes (PHTS). PHTS are due to germline mutations in PTEN gene. | * Proteus syndrome is one of the syndromes which falls under PTEN hamartoma tumor syndromes (PHTS). PHTS are due to germline mutations in PTEN gene. | ||
* PTEN hamartoma tumor syndromes (PHTS) which include the following: | * PTEN hamartoma tumor syndromes (PHTS) which include the following: | ||
** Proteus syndrome | |||
** Cowden syndrome | ** Cowden syndrome | ||
** Bannayan-Riley-Ruvalcaba syndrome | ** Bannayan-Riley-Ruvalcaba syndrome | ||
** Lhermitte-Duclos disease | ** Lhermitte-Duclos disease | ||
** Autism spectrum disorders | |||
** | ** | ||
Revision as of 13:57, 27 March 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Synonyms and keywords:PS
Overview
Proteus syndrome is an exceedingly rare disorder which falls under the category of hamartomatous disorder. Proteus syndrome is a very complex disorder which involves multiple organ systems in the body.
Historical Perspective
Discovery
- Proteus syndrome was first discovered by Frederick Treves, a British surgeon, in 1884.
- Frederick Treves showed the proteus syndrome on Joseph Merrick, who used to be called as the famous Elephant Man, to the Pathological Society of London.
Classification
- Proteus syndrome is one of the syndromes which falls under PTEN hamartoma tumor syndromes (PHTS). PHTS are due to germline mutations in PTEN gene.
- PTEN hamartoma tumor syndromes (PHTS) which include the following:
- Proteus syndrome
- Cowden syndrome
- Bannayan-Riley-Ruvalcaba syndrome
- Lhermitte-Duclos disease
- Autism spectrum disorders