Neurofibroma MRI: Difference between revisions

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[[File:Mri bladder mass gif.gif|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Axial T1-weighted MR image shows the bladder mass, which has predominantly low signal intensity. [https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]
[[File:Mri bladder mass gif.gif|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Axial T1-weighted MR image shows the bladder mass, which has predominantly low signal intensity. [https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]
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[[File:Sagittal mri.jpeg|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Sagittal, T2-weighted MR images show that the mass contains multiple areas of low signal intensity centrally and high signal intensity peripherally (arrow). This finding is referred to as the target sign and is suggestive of plexiform neurofibroma. [https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]  
[[File:Sagittal mri.jpeg|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Sagittal, T2-weighted MR image shows that the mass contains multiple areas of low signal intensity centrally and high signal intensity peripherally (arrow). This finding is referred to as the target sign and is suggestive of plexiform neurofibroma. [https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]  
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[[File:Axial mri gif.gif|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Axial T2-weighted MR images show that the mass contains multiple areas of low signal intensity centrally and high signal intensity peripherally. This finding is referred to as the target sign and is suggestive of plexiform neurofibroma.[https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]  
[[File:Axial mri gif.gif|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Axial T2-weighted MR image shows that the mass contains multiple areas of low signal intensity centrally and high signal intensity peripherally. This finding is referred to as the target sign and is suggestive of plexiform neurofibroma.[https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]
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[[File:Mri gd gif.gif|thumb|300px|none|Plexiform Neurofibroma of the Bladder. Axial unenhanced MR image shows mild nonuniform enhancement of the large bladder mass.[https://pubs.rsna.org/doi/10.1148/rg.24si035170#F1A Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]
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[[File:Enhanced gd gif.gif|thumb|300px|none|Plexiform Neurofibroma of the Bladder.Axial gadolinium-enhanced MR image shows mild nonuniform enhancement of the large bladder mass. Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.]]]  
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Revision as of 15:00, 27 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]

Overview

MRI may be helpful in the diagnosis of neurofibroma.

MRI

  • MRI may be helpful in the diagnosis of neurofibroma
  • MRI signal characteristics include:[1][2]
MRI sequence Characteristics
T1
  • Hypointense
  • Homogeneous low signal intensity
  • Center demonstrating a higher signal intensity than the periphery (reverse of target sign on T2)
T2
  • Hyperintense
  • Homogeneous high signal intensity (higher than fat)
  • Target sign (plexiform neurofibromas)
    • Low signal intensity centrally with a ring of high signal intensity peripherally
    • Due to a dense central area of collagenous stroma
    • Highly suggestive of neurofibroma but occasionally also seen in schwannomas and malignant peripheral nerve sheath tumors
  • Fascicular sign
  • Plexiform neurofibromas may appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement
  • Myxoid stroma enhancement helps differentiating the high signal intensity at T2-weighted imaging from cystic change or necrosis
T1 C+ (Gd) (with gadolinium contrast)
  • Heterogenous enhancement
Plexiform Neurofibroma of the Bladder. Axial unenhanced MR image shows mild nonuniform enhancement of the large bladder mass.Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.
Plexiform Neurofibroma of the Bladder. Axial T1-weighted MR image shows the bladder mass, which has predominantly low signal intensity. Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.
Plexiform Neurofibroma of the Bladder. Sagittal, T2-weighted MR image shows that the mass contains multiple areas of low signal intensity centrally and high signal intensity peripherally (arrow). This finding is referred to as the target sign and is suggestive of plexiform neurofibroma. Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.
Plexiform Neurofibroma of the Bladder. Axial T2-weighted MR image shows that the mass contains multiple areas of low signal intensity centrally and high signal intensity peripherally. This finding is referred to as the target sign and is suggestive of plexiform neurofibroma.Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.
Plexiform Neurofibroma of the Bladder.Axial gadolinium-enhanced MR image shows mild nonuniform enhancement of the large bladder mass. Source: Wilkinson LM. et al, From the Department of Medical Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.
]

References

  1. Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015
  2. https://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8


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