Neurofibroma laboratory findings: Difference between revisions
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**[[CD34]] (focal) | **[[CD34]] (focal) | ||
**Factor XIIIa (focal) | **Factor XIIIa (focal) | ||
**Neurofilament (and Bielshowsky) | **[[Neurofilament]] (and Bielshowsky) | ||
**GFAP | **[[GFAP]] | ||
**Calretinin (focal) | **[[Calretinin]] (focal) | ||
*Negative for: | *Negative for: | ||
**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]]) | **EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]]) | ||
**Keratin | **[[Keratin]] | ||
**Smooth muscle actin | **Smooth muscle actin | ||
**Desmin | **[[Desmin]] | ||
**Calponin | **[[Calponin]] | ||
**Caldesmon | **[[Caldesmon]] | ||
** | **[[P53]] | ||
{| class="wikitable" | {| class="wikitable" | ||
|+Immunohistochemical differences between Neurofibroma and Schwannoma | |+Immunohistochemical differences between Neurofibroma and Schwannoma | ||
| Line 29: | Line 29: | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma | ||
|- | |- | ||
|style="background:#DCDCDC;" align="center" + |'''S-100 and Sox10''' | | style="background:#DCDCDC;" align="center" + |'''[[S-100]] and Sox10''' | ||
|Moderate positivity | |Moderate positivity | ||
|Strong, diffuse positivity | |Strong, diffuse positivity | ||
|- | |- | ||
|style="background:#DCDCDC;" align="center" + |'''CD34''' | | style="background:#DCDCDC;" align="center" + |'''[[CD34]]''' | ||
|Moderate | |Moderate | ||
|Scattered cells in Antoni B areas | |Scattered cells in Antoni B areas | ||
|- | |- | ||
|style="background:#DCDCDC;" align="center" + |'''Neurofilament (and Bielshowsky)''' | | style="background:#DCDCDC;" align="center" + |'''[[Neurofilament]] (and Bielshowsky)''' | ||
|Stains entrapped axons within lesion | |Stains entrapped axons within lesion | ||
|Stains peripherally located axons of parent nerve | |Stains peripherally located axons of parent nerve | ||
|- | |- | ||
|style="background:#DCDCDC;" align="center" + |'''Factor XIIIa''' | | style="background:#DCDCDC;" align="center" + |'''Factor XIIIa''' | ||
|Moderate | |Moderate | ||
|Negative to focal | |Negative to focal | ||
|- | |- | ||
|style="background:#DCDCDC;" align="center" + |'''Calretinin''' | | style="background:#DCDCDC;" align="center" + |'''[[Calretinin]]''' | ||
|Negative to focal | |Negative to focal | ||
|Moderate | |Moderate | ||
|- | |- | ||
|style="background:#DCDCDC;" align="center" + |'''GFAP''' | | style="background:#DCDCDC;" align="center" + |'''[[GFAP]]''' | ||
|Variable, weak | |Variable, weak | ||
|Variable, moderate | |Variable, moderate | ||
Revision as of 20:21, 17 April 2019
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Neurofibroma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Neurofibroma laboratory findings On the Web |
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American Roentgen Ray Society Images of Neurofibroma laboratory findings |
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Risk calculators and risk factors for Neurofibroma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Immunohistochemistry of neurofibroma shows positivity for S100, CD34, and factor XIIIa and negativity for EMA (except in plexiform neurofibromas).
Laboratory Findings
Immunohistochemistry of neurofibroma is as follows:
- Positive for:
- S100
- Sox10
- CD34 (focal)
- Factor XIIIa (focal)
- Neurofilament (and Bielshowsky)
- GFAP
- Calretinin (focal)
- Negative for:
| Immunohistochemical stain | Neurofibroma | Schwannoma |
|---|---|---|
| S-100 and Sox10 | Moderate positivity | Strong, diffuse positivity |
| CD34 | Moderate | Scattered cells in Antoni B areas |
| Neurofilament (and Bielshowsky) | Stains entrapped axons within lesion | Stains peripherally located axons of parent nerve |
| Factor XIIIa | Moderate | Negative to focal |
| Calretinin | Negative to focal | Moderate |
| GFAP | Variable, weak | Variable, moderate |