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{{Osteosarcoma}}
{{Osteosarcoma}}
==Overview==
==Overview==
There are no established causes for osteosarcoma. However, some studies show that an increased level of [[C-Fos|c-fos]] [[proto-oncogene]] expression can lead to osteosarcoma.
There are no established exact causes for osteosarcoma. But physicians and medical researchers suggest that the the DNA mutations (either inherited or acquired after birth) inside the bone cellular system can be responsible for the occurrence of [[Osteosarcoma|OS]].
==Causes==
==Causes==
There are no established causes for osteosarcoma. However, some studies show that an increased level of [[C-Fos|c-fos]] [[proto-oncogene]] expression can lead to osteosarcoma. The study that showed this result was done on [[Transgenic organisms|transgenic mice]] in which the Fluid Sheer Stress (FSS) was increased to increase the number of [[osteoblasts]]. Since [[C-Fos|c-fos]] is ubiquitous in its overexpression, it can not only increase the [[osteoblasts]] resulting in the symptoms of osteosarcoma. Therefore it is believed that a biological effect that may cause osteosarcoma is an error in the molecular pathway that controls [[C-Fos|c-fos]], causing an overexpression with no other counter stimuli to stop over production.
The exact causes of [[Osteosarcoma|OS]] is not well-known, yet. However, a number of risk factors have been identified in this regard and please refer to the [[Osteosarcoma risk factors|risk factor section of this chapter]].


==References==
==References==

Revision as of 20:30, 2 April 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

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Overview

There are no established exact causes for osteosarcoma. But physicians and medical researchers suggest that the the DNA mutations (either inherited or acquired after birth) inside the bone cellular system can be responsible for the occurrence of OS.

Causes

The exact causes of OS is not well-known, yet. However, a number of risk factors have been identified in this regard and please refer to the risk factor section of this chapter.

References

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