Adult T-cell leukemia laboratory findings: Difference between revisions
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Latest revision as of 20:18, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
Laboratory findings consistent with the diagnosis of adult T-cell leukemia include abnormal anemia, thrombocytopenia, and elevated lymphocyte count. Hypercalcemia is a key feature among patients with adult T-cell leukemia.
Laboratory Findings
The following laboratory abnormalities may be observed in patients suffering from adult T-cell leukemia:[1][2][3]
Complete Blood Count
- Anemia
- Thrombocytopenia
- Elevated lymphocyte count
Basic Metabolic Panel
Peripheral Smear
- Characteristic leukemia cells with sharp nuclear indentations and a prominent nucleoli
- "Cloverleaf" or "flower" cells
Antibody Titres
- Detects antibodies present against HTLV antigens
Immunohistochemistry
References
- ↑ Matutes E (2007) Adult T-cell leukaemia/lymphoma. J Clin Pathol 60 (12):1373-7. DOI:10.1136/jcp.2007.052456 PMID: 18042693
- ↑ Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.
- ↑ Mahieux R, Gessain A (2007). "Adult T-cell leukemia/lymphoma and HTLV-1". Curr Hematol Malig Rep. 2 (4): 257–64. doi:10.1007/s11899-007-0035-x. PMID 20425378.