Retinoblastoma historical perspective: Difference between revisions
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*In 1809, Dr. James Wardrop, Scottish surgeon, an ophthalmologist, first described the retinoblastoma tumor. | *In 1809, Dr. James Wardrop, Scottish surgeon, an ophthalmologist, first described the retinoblastoma tumor. | ||
*In 1971, Dr. Knudson proposed the two-hit hypothesis which gives the light to the pathogenesis of the familial and sporadic form of the tumor.<ref name="pmid5279523">{{cite journal |vauthors=Knudson AG |title=Mutation and cancer: statistical study of retinoblastoma |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=68 |issue=4 |pages=820–3 |date=April 1971 |pmid=5279523 |pmc=389051 |doi= |url=}}</ref> | *In 1971, Dr. Knudson proposed the two-hit hypothesis which gives the light to the pathogenesis of the familial and sporadic form of the tumor.<ref name="pmid5279523">{{cite journal |vauthors=Knudson AG |title=Mutation and cancer: statistical study of retinoblastoma |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=68 |issue=4 |pages=820–3 |date=April 1971 |pmid=5279523 |pmc=389051 |doi= |url=}}</ref> | ||
*In | *In 1891, Dr. Flexner was the first to discover the rossette structure whithin the tumor.<ref name="Albert1987">{{cite journal|last1=Albert|first1=Daniel M.|title=Historic Review of Retinoblastoma|journal=Ophthalmology|volume=94|issue=6|year=1987|pages=654–662|issn=01616420|doi=10.1016/S0161-6420(87)33407-4}}</ref> | ||
*In 1920s Verhoeff claimed that the tumor arose from embryonic retinal cells and hence proposed the name "retinoblastoma". | *In 1920s Verhoeff claimed that the tumor arose from embryonic retinal cells and hence proposed the name "retinoblastoma". | ||
===Landmark Events in the Development of Treatment Strategies=== | ===Landmark Events in the Development of Treatment Strategies=== | ||
*In 1851, Mr. Helmholtz invented ophthalmoscope, with which the study of tumor became more possible.<ref name="Albert1987">{{cite journal|last1=Albert|first1=Daniel M.|title=Historic Review of Retinoblastoma|journal=Ophthalmology|volume=94|issue=6|year=1987|pages=654–662|issn=01616420|doi=10.1016/S0161-6420(87)33407-4}}</ref> | *In 1851, Mr. Helmholtz invented ophthalmoscope, with which the study of tumor became more possible.<ref name="Albert1987">{{cite journal|last1=Albert|first1=Daniel M.|title=Historic Review of Retinoblastoma|journal=Ophthalmology|volume=94|issue=6|year=1987|pages=654–662|issn=01616420|doi=10.1016/S0161-6420(87)33407-4}}</ref> | ||
*Dr. James Wardrop was also the first who proposed the idea that early enucleation of the eye might save the life of the patient. | *Dr. James Wardrop was also the first who proposed the idea that early enucleation of the eye might save the life of the patient. | ||
*William Mackenzie of Glasgow was the first who suggested a less painful method for the enucleation of the eye. | |||
In 1903, Dr. Hilgartner, was the first who tried to trat the tumor via x-ray. | |||
In 1953, Dr. Kupfer was the first ophthalmologist who tried a combination of chemotherapy (a nitrogen mustard agent intravenously) and radiotherapy for the treatment of the tumor. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:33, 19 April 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
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Overview
Retinoblastoma was first described in 1809 by James Wardrop.
Historical Perspective
- In 1657, Dr. Petrus Pawius, an anatomist from Amsterdam, described a tumor resembling retinoblastoma for the first time.[1]
- In 1767, Dr. Hayes, a surgeon, was first to describe the bilateral form of retinoblastoma.
- In 1809, Dr. James Wardrop, Scottish surgeon, an ophthalmologist, first described the retinoblastoma tumor.
- In 1971, Dr. Knudson proposed the two-hit hypothesis which gives the light to the pathogenesis of the familial and sporadic form of the tumor.[2]
- In 1891, Dr. Flexner was the first to discover the rossette structure whithin the tumor.[1]
- In 1920s Verhoeff claimed that the tumor arose from embryonic retinal cells and hence proposed the name "retinoblastoma".
Landmark Events in the Development of Treatment Strategies
- In 1851, Mr. Helmholtz invented ophthalmoscope, with which the study of tumor became more possible.[1]
- Dr. James Wardrop was also the first who proposed the idea that early enucleation of the eye might save the life of the patient.
- William Mackenzie of Glasgow was the first who suggested a less painful method for the enucleation of the eye.
In 1903, Dr. Hilgartner, was the first who tried to trat the tumor via x-ray. In 1953, Dr. Kupfer was the first ophthalmologist who tried a combination of chemotherapy (a nitrogen mustard agent intravenously) and radiotherapy for the treatment of the tumor.
References
- ↑ 1.0 1.1 1.2 Albert, Daniel M. (1987). "Historic Review of Retinoblastoma". Ophthalmology. 94 (6): 654–662. doi:10.1016/S0161-6420(87)33407-4. ISSN 0161-6420.
- ↑ Knudson AG (April 1971). "Mutation and cancer: statistical study of retinoblastoma". Proc. Natl. Acad. Sci. U.S.A. 68 (4): 820–3. PMC 389051. PMID 5279523.