Renal oncocytoma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2] Shanshan Cen, M.D. [3]

Overview

Renal oncocytoma must be differentiated from renal cell carcinoma, metanephric neoplasms, and renal leiomyoma.

Differential Diagnosis

Renal oncocytoma must be differentiated from:

• Renal cell carcinoma (RCC)
• Metanephric neoplasms

• Metanephric adenoma
• Metanephric adenofibroma

• Renal leiomyoma

Overview

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Differentiating [Disease name] from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases	Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
	Symptoms			Physical examination
							Lab Findings			Imaging			Histopathology
	Central scar	Papillary structures	Classic architectural pattern	Nuclei	CK7	KIT	Vimentin	AMACR	SDHB	Melanocytic markers	Imaging 2	Imaging 3
Oncocytoma	Classic but only subset	No or rare abortive		+			-		+
Chromophobe RCC, eosinophilic	Sometimes	No		+			-		+
Chromophobe RCC, classic	Sometimes	No		+			-		+
SDH-deficient RCC	Unknown	Usually no (rare variant cases)		- (mast cells present)			-		- (loss)
Papillary RCC, eosinophilic	Usually not	Yes		-			+		+
Tubulocystic RCC	Usually not	No		-			+		+
Epithelioid AML	Usually not	No		-			+		+