Oligodendroglioma surgery: Difference between revisions
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*[[Surgery|Surgical resection]] is the first-line treatment option for patients with oligodendroglioma.<ref name="rx">Treatment of oligodendroglioma. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/oligodendroglioma/?region=on</ref> | *[[Surgery|Surgical resection]] is the first-line treatment option for patients with oligodendroglioma.<ref name="rx">Treatment of oligodendroglioma. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/oligodendroglioma/?region=on</ref> | ||
*Because of their diffusely infiltrating nature, oligodendrogliomas cannot be completely resected. | *Because of their diffusely infiltrating nature, oligodendrogliomas cannot be completely resected. | ||
*The aim of surgery is to:<ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref><ref name="pmid27401154">{{cite journal| author=Kawaguchi T, Sonoda Y, Shibahara I, Saito R, Kanamori M, Kumabe T et al.| title=Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion. | journal=J Neurooncol | year= 2016 | volume= 129 | issue= 3 | pages= 505-514 | pmid=27401154 | doi=10.1007/s11060-016-2201-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27401154 }} </ref> | *The aim of surgery is to:<ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref><ref name="pmid27401154">{{cite journal| author=Kawaguchi T, Sonoda Y, Shibahara I, Saito R, Kanamori M, Kumabe T et al.| title=Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion. | journal=J Neurooncol | year= 2016 | volume= 129 | issue= 3 | pages= 505-514 | pmid=27401154 | doi=10.1007/s11060-016-2201-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27401154 }} </ref><ref name="pmid30467813">{{cite journal| author=Delev D, Heiland DH, Franco P, Reinacher P, Mader I, Staszewski O et al.| title=Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system. | journal=J Neurooncol | year= 2019 | volume= 141 | issue= 1 | pages= 223-233 | pmid=30467813 | doi=10.1007/s11060-018-03030-w | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30467813 }} </ref> | ||
**Make a definitive diagnosis | **Make a definitive diagnosis | ||
**Debulk the [[tumor]] to relieve [[elevated intracranial pressure]] | **Debulk the [[tumor]] to relieve [[elevated intracranial pressure]] | ||
Revision as of 15:28, 2 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]
Overview
Surgery is the first-line treatment option for patients with oligodendroglioma. CSF shunting is usually reserved for patients with hydrocephalus.
Surgery
Surgical Resection
- Surgical resection is the first-line treatment option for patients with oligodendroglioma.[1]
- Because of their diffusely infiltrating nature, oligodendrogliomas cannot be completely resected.
- The aim of surgery is to:[2][3][4]
- Make a definitive diagnosis
- Debulk the tumor to relieve elevated intracranial pressure
- Reduce the tumor mass as a precursor to adjuvant treatment
CSF Shunt
- CSF shunting is performed to relieve the pressure in the brain due to blockade in the flow of cerebrospinal fluid due to oligodendroglioma.[5]
- External ventricular drain - temporary shunt
- Internal drain - permanent shunt
- Drains CSF into the patient’s abdomen where it is absorbed into the body
References
- ↑ Treatment of oligodendroglioma. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/oligodendroglioma/?region=on
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Kawaguchi T, Sonoda Y, Shibahara I, Saito R, Kanamori M, Kumabe T; et al. (2016). "Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion". J Neurooncol. 129 (3): 505–514. doi:10.1007/s11060-016-2201-2. PMID 27401154.
- ↑ Delev D, Heiland DH, Franco P, Reinacher P, Mader I, Staszewski O; et al. (2019). "Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system". J Neurooncol. 141 (1): 223–233. doi:10.1007/s11060-018-03030-w. PMID 30467813.
- ↑ Stark AM, Hugo HH, Mehdorn HM, Knerlich-Lukoschus F (2009). "Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma". Case Rep Med. 2009: 370901. doi:10.1155/2009/370901. PMC 2797365. PMID 20052406.