Oligodendroglioma laboratory tests: Difference between revisions
Jump to navigation
Jump to search
Sara Mohsin (talk | contribs) |
Sara Mohsin (talk | contribs) |
||
Line 9: | Line 9: | ||
===Lumbar Puncture=== | ===Lumbar Puncture=== | ||
*Some patients with oligodendroglioma may have elevated [[protein]] and cell count with normal [[glucose]] and [[lactate]] on [[lumbar puncture|CSF analysis]], which is usually suggestive of [[hydrocephalus]]<ref name="pmid20052406">{{cite journal| author=Stark AM, Hugo HH, Mehdorn HM, Knerlich-Lukoschus F| title=Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma. | journal=Case Rep Med | year= 2009 | volume= 2009 | issue= | pages= 370901 | pmid=20052406 | doi=10.1155/2009/370901 | pmc=PMC2797365 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20052406 }} </ref><ref name="pmid16048288">{{cite journal| author=Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F et al.| title=Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas. | journal=Neurosurg Focus | year= 2005 | volume= 18 | issue= 6A | pages= E2 | pmid=16048288 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16048288 }} </ref> | *Some patients with oligodendroglioma may have elevated [[protein]] and cell count with normal [[glucose]] and [[lactate]] on [[lumbar puncture|CSF analysis]], which is usually suggestive of [[hydrocephalus]]<ref name="pmid20052406">{{cite journal| author=Stark AM, Hugo HH, Mehdorn HM, Knerlich-Lukoschus F| title=Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma. | journal=Case Rep Med | year= 2009 | volume= 2009 | issue= | pages= 370901 | pmid=20052406 | doi=10.1155/2009/370901 | pmc=PMC2797365 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20052406 }} </ref><ref name="pmid16048288">{{cite journal| author=Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F et al.| title=Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas. | journal=Neurosurg Focus | year= 2005 | volume= 18 | issue= 6A | pages= E2 | pmid=16048288 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16048288 }} </ref> | ||
===Immunohistochemical staining=== | |||
*Oligodendrogliomas stain positive for: | |||
**R132H-IDH1 (majority of cases) | |||
**ATRX | |||
**GFAP (positive in intermingled reactive astrocytes and minigemistocytes) | |||
**Olig2 | |||
**SOX10 | |||
**MAP2 | |||
**S100 | |||
*Oligodendrogliomas stain negative for: | |||
**p53 (rare weakly positive cells can be seen) | |||
**Keratins (although cocktails may show cross reactivity) | |||
==References== | ==References== |
Revision as of 23:25, 7 May 2019
Oligodendroglioma Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Oligodendroglioma laboratory tests On the Web |
American Roentgen Ray Society Images of Oligodendroglioma laboratory tests |
Risk calculators and risk factors for Oligodendroglioma laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]
Overview
Some patients with oligodendroglioma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus.
Laboratory Findings
Lumbar Puncture
- Some patients with oligodendroglioma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus[1][2]
Immunohistochemical staining
- Oligodendrogliomas stain positive for:
- R132H-IDH1 (majority of cases)
- ATRX
- GFAP (positive in intermingled reactive astrocytes and minigemistocytes)
- Olig2
- SOX10
- MAP2
- S100
- Oligodendrogliomas stain negative for:
- p53 (rare weakly positive cells can be seen)
- Keratins (although cocktails may show cross reactivity)
References
- ↑ Stark AM, Hugo HH, Mehdorn HM, Knerlich-Lukoschus F (2009). "Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma". Case Rep Med. 2009: 370901. doi:10.1155/2009/370901. PMC 2797365. PMID 20052406.
- ↑ Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F; et al. (2005). "Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas". Neurosurg Focus. 18 (6A): E2. PMID 16048288.