Neoplastic meningitis: Difference between revisions
Jump to navigation
Jump to search
| Line 10: | Line 10: | ||
==[[Neoplastic meningitis overview|Overview]]== | ==[[Neoplastic meningitis overview|Overview]]== | ||
==[[Neoplastic meningitis historical perspective|Historical Perspective]]== | ==[[Neoplastic meningitis historical perspective|Historical Perspective]]== | ||
* | |||
==[[Neoplastic meningitis classification|Classification]]== | ==[[Neoplastic meningitis classification|Classification]]== | ||
==[[Neoplastic meningitis pathophysiology|Pathophysiology]]== | ==[[Neoplastic meningitis pathophysiology|Pathophysiology]]== | ||
* The pathophysiology of neoplastic meningitis involves spread of cancer cells to the meninges and subarachnoid space. The location could be the brain or the spinal cord. It could be from a distant source or from a primary CNS tumor (drop metastasis. | * The pathophysiology of neoplastic meningitis involves spread of cancer cells to the meninges and subarachnoid space. The location could be the brain or the spinal cord. It could be from a distant source or from a primary CNS tumor (drop metastasis). | ||
* Cancer from a distant source enter the CSF by means of the following:[https://en.wikipedia.org/wiki/Neoplastic_meningitis] | * Cancer from a distant source enter the CSF by means of the following:[https://en.wikipedia.org/wiki/Neoplastic_meningitis] | ||
** Hematogenous Spread - cancer cells invade blood vessels to reach the subarachnoid space through the systemic arterial circulation or by the Batsons venous plexus. | ** Hematogenous Spread - cancer cells invade blood vessels to reach the subarachnoid space through the systemic arterial circulation or by the Batsons venous plexus. | ||
** Infiltration to the spinal cord - | ** Infiltration to the spinal cord - | ||
** Cancer spread a neural pathways to reach the meninges <ref>{{Cite journal|last=Fields|first=Margaret|date=May - June 2013|title=How to Recognize and Treat Neoplastic Meningitis|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093424/|journal=Journal of the Advanced Practitioner in Oncology|volume=4 (3)|pages=155-160|via=}}</ref> | |||
** Iatrogenic - from surgical procedures involving removal of a primary brain tumor | |||
** | ** | ||
==[[Neoplastic meningitis causes|Causes]]== | ==[[Neoplastic meningitis causes|Causes]]== | ||
* Neoplastic meningitis is a secondary cancer caused by the spread of tumor cells into the meninges and subarachnoid space from a primary source. Most common sources documented are breast, lung, melanoma and hematologic cancers mostly acute lymphocytic leukemia.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093424/] | * Neoplastic meningitis is a secondary cancer caused by the spread of tumor cells into the meninges and subarachnoid space from a primary source. Most common sources documented are breast, lung, melanoma and hematologic cancers mostly acute lymphocytic leukemia. Cancers not previously thought to be predisposed to neoplastic meningitis but now has documented cases are gastric, prostate, ovarian, cervical and endometrial. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093424/] | ||
==[[Neoplastic meningitis differential diagnosis|Differentiating Neoplastic Meningitis from other Diseases]]== | ==[[Neoplastic meningitis differential diagnosis|Differentiating Neoplastic Meningitis from other Diseases]]== | ||
Revision as of 06:12, 12 May 2019
|
Neoplastic meningitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Neoplastic meningitis On the Web |
|
American Roentgen Ray Society Images of Neoplastic meningitis |
For patient information, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and keywords: NM; Carcinomatous meningitis; Leptomeningeal carcinomatosis; LC; Neoplastic arachnoiditis; Malignant meningitis; Leptomeningeal neoplasia, Meningeal carcinomatosis; Meningeosis neoplastica; Meningitis carcinomatosa; Leptomeningeal metastasis; Leptomeningeal metastases; Carcinomatous meningitis; Subarachnoid space metastasis; Subarachnoid space metastases
Overview
Historical Perspective
Classification
Pathophysiology
- The pathophysiology of neoplastic meningitis involves spread of cancer cells to the meninges and subarachnoid space. The location could be the brain or the spinal cord. It could be from a distant source or from a primary CNS tumor (drop metastasis).
- Cancer from a distant source enter the CSF by means of the following:[3]
- Hematogenous Spread - cancer cells invade blood vessels to reach the subarachnoid space through the systemic arterial circulation or by the Batsons venous plexus.
- Infiltration to the spinal cord -
- Cancer spread a neural pathways to reach the meninges [1]
- Iatrogenic - from surgical procedures involving removal of a primary brain tumor
Causes
- Neoplastic meningitis is a secondary cancer caused by the spread of tumor cells into the meninges and subarachnoid space from a primary source. Most common sources documented are breast, lung, melanoma and hematologic cancers mostly acute lymphocytic leukemia. Cancers not previously thought to be predisposed to neoplastic meningitis but now has documented cases are gastric, prostate, ovarian, cervical and endometrial. [4]
Differentiating Neoplastic Meningitis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging | History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
- ↑ Fields, Margaret (May - June 2013). "How to Recognize and Treat Neoplastic Meningitis". Journal of the Advanced Practitioner in Oncology. 4 (3): 155–160. Check date values in:
|date=(help)