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*Other diagnostic studies for glomus tumor include [[immunohistochemistry]] staining, which demonstrates the following:<ref name="pmid1848411">{{cite journal| author=Kaye VM, Dehner LP| title=Cutaneous glomus tumor. A comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi. | journal=Am J Dermatopathol | year= 1991 | volume= 13 | issue= 1 | pages= 2-6 | pmid=1848411 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1848411 }} </ref> | *Other diagnostic studies for glomus tumor include [[immunohistochemistry]] staining, which demonstrates the following:<ref name="pmid1848411">{{cite journal| author=Kaye VM, Dehner LP| title=Cutaneous glomus tumor. A comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi. | journal=Am J Dermatopathol | year= 1991 | volume= 13 | issue= 1 | pages= 2-6 | pmid=1848411 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1848411 }} </ref> | ||
**Glomus cells stain positive for: | **Glomus cells stain positive for: | ||
***Alpha-smooth muscle actin (αSMA) | |||
***Alpha-smooth muscle actin (~100% | ****~100% | ||
***MSA | |||
****95% | |||
***[[Vimentin]] | |||
**Glomus cells stain negative for: | **Glomus cells stain negative for: | ||
***[[Desmin]] | ***[[Desmin]] | ||
*** | ***CD31 | ||
***Cytokeratins | |||
***S100 | ***S100 | ||
* | * Other diagnostic studies for glomus tumors include clinical tests, such as: | ||
** '''Love test'''<ref name="pmid15215032">{{cite journal| author=Pater TJ, Marks RM| title=Glomus tumor of the hallux: case presentation and review of the literature. | journal=Foot Ankle Int | year= 2004 | volume= 25 | issue= 6 | pages= 434-7 | pmid=15215032 | doi=10.1177/107110070402500614 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15215032 }}</ref><ref name="pmid7985967">{{cite journal| author=Rohrich RJ, Hochstein LM, Millwee RH| title=Subungual glomus tumors: an algorithmic approach. | journal=Ann Plast Surg | year= 1994 | volume= 33 | issue= 3 | pages= 300-4 | pmid=7985967 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7985967 }} </ref> | ** '''Love test'''<ref name="pmid15215032">{{cite journal| author=Pater TJ, Marks RM| title=Glomus tumor of the hallux: case presentation and review of the literature. | journal=Foot Ankle Int | year= 2004 | volume= 25 | issue= 6 | pages= 434-7 | pmid=15215032 | doi=10.1177/107110070402500614 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15215032 }}</ref><ref name="pmid7985967">{{cite journal| author=Rohrich RJ, Hochstein LM, Millwee RH| title=Subungual glomus tumors: an algorithmic approach. | journal=Ann Plast Surg | year= 1994 | volume= 33 | issue= 3 | pages= 300-4 | pmid=7985967 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7985967 }} </ref> | ||
*** Orientative | *** Orientative | ||
Revision as of 23:10, 15 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2] Roukoz A. Karam, M.D.[3]
Overview
Other diagnostic studies for glomus tumor include immunohistochemistry staining, which demonstrates glomus cells positive for vimentin and alpha-smooth muscle actin and negative for desmin.[1]
Other Diagnostic Studies
- Other diagnostic studies for glomus tumor include immunohistochemistry staining, which demonstrates the following:[1]
- Other diagnostic studies for glomus tumors include clinical tests, such as:
- Love test[2][3]
- Orientative
- Probing with a needle or pointed instrument triggers pain in the affected area but not the area immediately adjacent to it
- Sensitivity= 100%
- Specificity= 0%
- Hildreth sign[2]
- Occurence of pain following induction of ischemia by application of a tourniquet to the glomus tumor mimicking median nail dystrophy (the longitudinal splitting in the midline of the nail)
- Highlights the vascular nature of the lesion
- Sensitivity= 77.4% - 92%
- Specificity= 91% - 100%
- Cold-sensitivity test[4]
- Application of cold water or ethanol to the affected area reproducing the symptoms
- Sensitivity= 100%
- Specificity= 100%
- Transillumination test[4][5]
- Performed in a darkened room by passing light through the finger pad
- An opaque red image is observed in the region of the tumor that allows estimation of its size
- Sensitivity= 23% - 38%
- Specificity= 90%
- Love test[2][3]
References
- ↑ 1.0 1.1 Kaye VM, Dehner LP (1991). "Cutaneous glomus tumor. A comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi". Am J Dermatopathol. 13 (1): 2–6. PMID 1848411.
- ↑ 2.0 2.1 Pater TJ, Marks RM (2004). "Glomus tumor of the hallux: case presentation and review of the literature". Foot Ankle Int. 25 (6): 434–7. doi:10.1177/107110070402500614. PMID 15215032.
- ↑ Rohrich RJ, Hochstein LM, Millwee RH (1994). "Subungual glomus tumors: an algorithmic approach". Ann Plast Surg. 33 (3): 300–4. PMID 7985967.
- ↑ 4.0 4.1 Kale SS, Rao VK, Bentz ML (2006). "Glomus tumor of the index finger". J Craniofac Surg. 17 (4): 801–4. PMID 16877938.
- ↑ Ekin A, Ozkan M, Kabaklioglu T (1997). "Subungual glomus tumours: a different approach to diagnosis and treatment". J Hand Surg Br. 22 (2): 228–9. PMID 9149994.