Oligodendroglioma other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
*Biopsy may be performed to help confirm the diagnosis of oligodendroglioma | *[[Biopsy]] may be [[Performance status|performed]] to help [[Confirmatory factor analysis|confirm]] the [[diagnosis]] of [[oligodendroglioma]] | ||
*On [[biopsy]], oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885 }} </ref> | *On [[biopsy]], [[oligodendroglioma]] is characterized by [[homogeneous]], [[Compact tissue|compact]], rounded [[Cell (biology)|cells]] with [[Distinctive feature|distinct]] borders and clear [[cytoplasm]] surrounding a [[dense]] [[central]] [[nucleus]] and [[Perinuclear space|perinuclear]] [[Halo (medicine)|halo]], giving it the characteristic “''fried [[Egg (biology)|egg]]''” [[appearance]]<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885 }} </ref> | ||
*Biopsy may be done at the time of [[surgical resection]] of oligodendroglioma | *[[Biopsy]] may be done at the [[Time series|time]] of [[surgical resection]] of [[oligodendroglioma]] | ||
*Biopsy may be of two types: | *[[Biopsy]] may be of two types: | ||
**Open biopsy | **Open [[biopsy]] | ||
**[[stereotactic|Stereotactic biopsy]] | **[[stereotactic|Stereotactic biopsy]] | ||
*Indications for open biopsy and [[stereotactic|stereotactic biopsy]] are described below:<ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref> | *[[Indications and usage|Indications]] for open [[biopsy]] and [[stereotactic|stereotactic biopsy]] are described below:<ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref> | ||
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===Fluorescent in-situ hybridization (FISH) technique=== | ===Fluorescent in-situ hybridization (FISH) technique=== | ||
*[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]<ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref> | *[[FISH]] demonstrates [[Deletion (genetics)|deletions]] of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]<ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref> | ||
==References== | ==References== | ||
Revision as of 23:27, 18 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]
Overview
Other diagnostic studies for oligodendroglioma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).
Other Diagnostic Studies
Biopsy
- Biopsy may be performed to help confirm the diagnosis of oligodendroglioma
- On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance[1]
- Biopsy may be done at the time of surgical resection of oligodendroglioma
- Biopsy may be of two types:
- Indications for open biopsy and stereotactic biopsy are described below:[2]
| Type of biopsy | Indications |
|---|---|
|
Fluorescent in-situ hybridization (FISH) technique
- FISH demonstrates deletions of chromosome 1p and 19q[3]
References
- ↑ Wesseling P, van den Bent M, Perry A (2015). "Oligodendroglioma: pathology, molecular mechanisms and markers". Acta Neuropathol. 129 (6): 809–27. doi:10.1007/s00401-015-1424-1. PMC 4436696. PMID 25943885.
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 9 October, 2015 Check date values in:
|accessdate=(help)