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| {{Familial mediterranean fever}} | | {{Familial mediterranean fever}} |
| {{CMG}}; {{AE}} | | {{CMG}}; {{AE}} |
| == Overview ==
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| | | {{familytree | | | | | | | | | | | | | | | | | | | | | | A01 | | | | | |A01=system-based symptoms of FMF}} |
| == Diagnostic Study of Choice == | | {{familytree | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | |}} |
| | | {{familytree | |,|-|-|-|-|-|v|-|-|-|-|-|v|-|-|-|-|-|v|-|-|-|-|-|v|-|-|-|-|-|+|-|-|-|-|-|v|-|-|-|-|-|.| | }} |
| === Study of choice ===
| | {{familytree | |!| | | | | |!| | | | | |!| | | | | |!| | | | | |!| | | | | |!| | | | | |!| | | | | |!| | }} |
| Familial Mediterranean fever is primarily diagnosed based on the clinical presentation.
| | {{familytree | D01 | | | | D02 | | | | D03 | | | | D04 | | | | D05 | | | | D06 | | | | D07 | | | | D08 | |D01=Gastrointestinal system|D02=Reticuloendothelial system|D03=Musculoskeletal system |D04=Axial spine|D05=Cardiovascular system}} |
| | | {{familytree | |!| | | | | |!| | | | | |!| | | | | |!| | | | | |!| | }} |
| ==== The comparison of various diagnostic studies for familial Mediterranean fever==== | | {{familytree | E01 | | | | E02 | | | | E03 | | | | E04 | | | | E05 | |E01=|E02=|E03=|E04=|E05=}} |
| {| | |
| |- style="background: #4479BA; color: #FFFFFF; text-align: center;" | |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Test | |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Sensitivity | |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specificity | |
| |- | |
| ! style="background: #696969; color: #FFFFFF; text-align: center;" |Tel Hashomer criteria | |
| | style="background: #DCDCDC; padding: 5px; text-align: center;" |...% | |
| | style="background: #DCDCDC; padding: 5px; text-align: center;" |...% | |
| |- | |
| ! style="background: #696969; color: #FFFFFF; text-align: center;" |Livneh criteria | |
| | style="background: #DCDCDC; padding: 5px; text-align: center;" |...% | |
| | style="background: #DCDCDC; padding: 5px; text-align: center;" |...% | |
| |} | | |} |
| <small> [Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity</small>
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| ==== The Tel Hashomer for diagnosing familial Mediterranean fever====
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| {|
| |
| |- style="background: #4479BA; color: #FFFFFF; text-align: center;"
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Type
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Criteria
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| |-
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| ! style="background: #696969; color: #FFFFFF; text-align: center;" |Major
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| | style="background: #DCDCDC; padding: 5px; text-align: left;" |I. Recurrent episodes of fever plus serositis
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| II. AA type of amyloidosis without predisposing disease
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| III. Response to colchicine
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| |-
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| ! style="background: #696969; color: #FFFFFF; text-align: center;" |Minor
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| | style="background: #DCDCDC; padding: 5px; text-align: left;" |I. Recurrent febrile attacks
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| II. Erysipelas-like erythema
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| III. Family history in first-degree relatives
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| |}
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| ==== The Livneh criteria for diagnosing familial Mediterranean fever<ref name="pmid9336425">{{cite journal |vauthors=Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M |title=Criteria for the diagnosis of familial Mediterranean fever |journal=Arthritis Rheum. |volume=40 |issue=10 |pages=1879–85 |date=October 1997 |pmid=9336425 |doi=10.1002/1529-0131(199710)40:10<1879::AID-ART23>3.0.CO;2-M |url=}}</ref>====
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| {|
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| |- style="background: #4479BA; color: #FFFFFF; text-align: center;"
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Type
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Criteria
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| |-
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| ! style="background: #696969; color: #FFFFFF; text-align: center;" |Major
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| | style="background: #DCDCDC; padding: 5px; text-align: left;" |Typical attacks (1-4)
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| 1- Generalised peritonitis
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| 2- Unilateral pleuritis or pericarditis
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| 3- Monoarthritis (hip, knee, ankle)
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| 4- Fever alone
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| 5- Incomplete abdominal attack
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| |-
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| ! style="background: #696969; color: #FFFFFF; text-align: center;" |Minor
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| | style="background: #DCDCDC; padding: 5px; text-align: left;" |Incomplete attacks involving either or both
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| of the following sites
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| 1- Chest
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| 2- Joint
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| 3- Exertional leg pain
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| 4- Favorable response to colchicine
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| |}
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| ===Tel Hashomer criteria===
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| [Disease name] may be diagnosed at any time if one or more of the following criteria are met:
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| * Criteria 1
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| * Criteria 2
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| * Criteria 3
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| The diagnosis of Familial Mediterranean fever is made when at least 2 of the following diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
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| ==References==
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| {{Reflist|2}}
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